AI Article Synopsis
- The study investigates how air pollution, specifically ozone exposure during pregnancy, affects maternal health by examining its impact on blood pressure and body temperature in a rat model.
- Researchers observed that rats exposed to ozone experienced lower heart rates and body temperatures compared to those not exposed, alongside a slight increase in arterial blood pressure that continued until delivery.
- The findings support the use of animal models to better understand cardiovascular issues related to air pollution during pregnancy, highlighting an area of concern for maternal and fetal health.
Article Abstract
The contribution of air pollution-induced cardiopulmonary damage on the development of hypertensive disorders of pregnancy and other adverse outcomes of pregnancy has gained increased attention as epidemiological data continue to highlight spatiotemporal pregnancy trends related to air pollution exposure. However clinical mechanistic data surrounding gestational complications remain sparse, necessitating the need for the use of animal models to study these types of complications of pregnancy. The current study seeks to examine the real-time effects of mid-gestational ozone exposure on maternal blood pressure and body temperature through the use of radiotelemetry in a rat model. The exposure resulted in acute depression of heart rate and core body temperature as compared to control animals. Ozone-exposed animals also presented with a slight but significant increase in arterial blood pressure which was perpetuated until term. The data presented here illustrates the feasibility of murine models to assess cardiovascular complications caused by inhaled toxicants during the window of pregnancy.
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| http://dx.doi.org/10.1007/s12012-024-09887-w | DOI Listing |
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