AI Article Synopsis
- * A study involving 100 MS patients found that the rate of amyloid-β biomarker positivity was about half compared to 300 non-MS controls, indicating a lower risk of Alzheimer’s in MS patients.
- * Most MS patients with amyloid-β pathology exhibited atypical symptoms for MS, suggesting that the relationship between MS and Alzheimer’s disease could lead to new research opportunities.
Article Abstract
The life expectancy of people with multiple sclerosis (MS) has increased, yet we have noted that development of a typical Alzheimer disease dementia syndrome is uncommon. We hypothesized that Alzheimer disease pathology is uncommon in MS patients. In 100 MS patients, the rate of amyloid-β plasma biomarker positivity was approximately half the rate in 300 non-MS controls matched on age, sex, apolipoprotein E proteotype, and cognitive status. Interestingly, most MS patients who did have amyloid-β pathology had features atypical for MS at diagnosis. These results support that MS is associated with reduced Alzheimer disease risk, and suggest new avenues of research. ANN NEUROL 2024;96:453-459.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11324391 | PMC |
| http://dx.doi.org/10.1002/ana.27027 | DOI Listing |
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