AI Article Synopsis
- * Modern detection methods now allow for earlier identification of these metabolites in drug development, helping to prevent DILI before it occurs.
- * Ongoing studies into enzyme interactions and genetic differences are enhancing predictions of DILI risk, ultimately refining drug safety evaluations and supporting personalized medicine approaches.
Article Abstract
Advances in the field of bioactivation have significantly contributed to our understanding and prediction of drug-induced liver injury (DILI). It has been established that many adverse drug reactions, including DILI, are associated with the formation and reactivity of metabolites. Modern methods allow us to detect and characterize these reactive metabolites in earlier stages of drug development, which helps anticipate and circumvent the potential for DILI. Improved models and experimental techniques that better reflect environments are enhancing predictive capabilities for DILI risk. Further, studies on the mechanisms of bioactivation, including enzyme interactions and the role of individual genetic differences, have provided valuable insights for drug optimizations. Cumulatively, this progress is continually refining our approaches to drug safety evaluation and personalized medicine.
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| http://dx.doi.org/10.1080/03602532.2024.2376023 | DOI Listing |
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