AI Article Synopsis
- Diabetes mellitus, particularly type 2 diabetes (T2DM), is a growing global health concern characterized by high blood sugar levels and can lead to diabetic kidney disease (DKD), affecting about one-third of diabetes patients.
- DKD primarily results in weakened kidney function and is a leading cause of end-stage kidney disease (ESKD), with T2DM being a major contributor.
- Research indicates a link between vitamin D deficiency and the progression of T2DM, suggesting that vitamin D metabolism and vitamin D receptor (VDR) signaling may play important roles in the development of DKD.
Article Abstract
Diabetes mellitus is a metabolic disorder characterized by high blood sugar levels. In recent years, T2DM has become a worldwide health issue due to an increase in incidence and prevalence. Diabetic kidney disease (DKD) is one of the devastating consequences of diabetes, especially owing to T2DM and the key clinical manifestation of DKD is weakened renal function and progressive proteinuria. DKD affects approximately 1/3rd of patients with diabetes mellitus, and T2DM is the predominant cause of end-stage kidney disease (ESKD). Several lines of studies have observed the association between vitamin D deficiency and the progression and etiology of type II diabetes mellitus. Emerging experimental evidence has shown that T2DM is associated with various kinds of kidney diseases. Recent evidence has also shown that an alteration in VDR (vitamin D receptor) signaling in podocytes leads to DKD. The present review aims to examine vitamin D metabolism and its correlation with T2DM. Furthermore, we discuss the potential role of vitamin D and VDR in diabetic kidney disease.
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| http://dx.doi.org/10.2174/0113816128296168240614071821 | DOI Listing |
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