AI Article Synopsis
- Hypomagnesemia is a common side effect of anti-EGFR antibodies, potentially leading to arrhythmia, but there are no established guidelines for magnesium supplementation in these patients.
- A systematic review was conducted, analyzing articles until mid-2021, focusing on the relationship between anti-EGFR antibodies and hypomagnesemia.
- One study indicated that magnesium supplementation could help manage hypomagnesemia in patients treated with cetuximab, but more research is needed to determine its impact on preventing arrhythmias.
Article Abstract
Background/aim: Hypomagnesemia is a common side effect of anti-epidermal growth factor receptor (EGFR) antibodies, which may lead to arrhythmia. However, there are no evidence-based guidelines for magnesium (Mg) supplementation in the management of hypomagnesemia in patients with anti-EGFR antibodies. Therefore, we performed a systematic review to address clinical questions regarding these cancer patients.
Materials And Methods: Three electronic databases were searched for articles published until June 18, 2021. The main outcomes used were "anti-EGFR antibody" and "hypomagnesemia".
Results: After screening 78 references in PubMed, Cochrane Library, and ICHUSHI-web databases, three studies were included in the review. One study revealed the effectiveness of Mg supplementation in the management of hypomagnesemia in patients receiving cetuximab. However, no studies have investigated whether correcting hypomagnesemia can lead to the suppression of arrhythmias as a clinical outcome.
Conclusion: Weak evidence suggests that Mg supplementation, as a preventive measure when developing hypomagnesemia following the initiation of anti-EGFR antibody therapy, may prevent the worsening of hypomagnesemia, and subsequently prevent associated arrhythmia occurrence.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11215447 | PMC |
| http://dx.doi.org/10.21873/cdp.10337 | DOI Listing |
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