This study investigates HLA-DR expression on activated T cells and serum neopterin levels in Juvenile Dermatomyositis (JDM) children pre- and post-treatment. Sixty-nine JDM children (less than 18 years) were included. Elevated HLA-DR+ cells (>7 %) were observed in 19 % of untreated cases. Post-treatment, mean HLA-DR+ cells decreased from 5.1 to 2.9 ( < 0.001), and serum neopterin levels declined from 19.3 to 9.1 nmol/L ( < 0.0001). A positive correlation between serum neopterin and HLA-DR T cell percentage was observed ( = 0.39, = 0.01). Intravenous steroid treatment exhibited a 47.4 % improvement in HLA-DR+ cells and a 50.5 % reduction in serum neopterin levels, in contrast to 14.8 % and 34.1 % in the oral steroid group. In conclusion, treatment, particularly with IV steroids, significantly improved HLA-DR+ cells percentage and neopterin levels. A correlation between HLA-DR+ cells percentage and serum neopterin was noted in untreated JDM patients.
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| http://dx.doi.org/10.1016/j.clicom.2024.02.002 | DOI Listing |
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