AI Article Synopsis
- Scientists are studying how the gut bacteria can affect brain diseases like epilepsy and found that an antibiotic called ciprofloxacin might make seizures more likely.
- They used special tests to see how ciprofloxacin changes gut bacteria and causes seizures in rats, discovering that this antibiotic messes up the gut health.
- The researchers think that fixing the gut bacteria can help reduce seizures, which could lead to better treatments for epilepsy in the future.
Article Abstract
Introduction: The gut microbiota and the microbiota-gut-brain axis have gained considerable attention in recent years, emerging as key players in the mechanisms that mediate the occurrence and progression of many central nervous system-related diseases, including epilepsy. In clinical practice, one of the side effects of quinolone antibiotics is a lower seizure threshold or aggravation. However, the underlying mechanism remains unclear.
Methods: We aimed to unravel the intrinsic mechanisms through rRNA sequencing and serum untargeted metabolomic analysis to shed light on the effects of gut microbiota in ciprofloxacin-induced seizure susceptibility and lithium pilocarpine-induced epilepsy rat models.
Results: We observed that ciprofloxacin treatment increased seizure susceptibility and caused gut dysbiosis. We also found similar changes in the gut microbiota of rats with lithium pilocarpine-induced epilepsy. Notably, the levels of and significantly increased in both the ciprofloxacin-induced seizure susceptibility and lithium pilocarpine-induced epilepsy rat models. However, , and showed a coincidental reduction. Additionally, the serum untargeted metabolomic analysis revealed decreased levels of indole-3-propionic acid, a product of tryptophan-indole metabolism, after ciprofloxacin treatment, similar to those in the plasma of lithium pilocarpine-induced epilepsy in rats. Importantly, alterations in the gut microbiota, seizure susceptibility, and indole-3-propionic acid levels can be restored by fecal microbiota transplantation.
Conclusion: In summary, our findings provide evidence that ciprofloxacin-induced seizure susceptibility is partially mediated by the gut microbiota and tryptophan-indole metabolism. These associations may play a role in epileptogenesis, and impacting the development progression and treatment outcomes of epilepsy.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11220169 | PMC |
| http://dx.doi.org/10.3389/fmicb.2024.1403892 | DOI Listing |
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