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Evaluation of an automated assay for eosinophil-derived neurotoxin in serum.
Clin Biochem
January 2025
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, United states. Electronic address:
Introduction: Eosinophil-derived neurotoxin (EDN) is a promising biomarker for eosinophil activation during inflammatory responses. Here we evaluate the analytical performance of an automated fluorescence enzyme immunoassay for EDN in serum and explore its relationship with eosinophil counts in both healthy participants and those with eosinophilic conditions.
Materials And Methods: Paired serum samples were collected from individuals for whom a complete blood count with differential was ordered.
Comparison of statistical evaluation approaches for log-removal validation according to European water reuse regulations.
Sci Total Environ
January 2025
Institute of Environmental Engineering, RWTH Aachen University, Mies-van-der-Rohe Strasse 1, 52066 Aachen, Germany.
In 2020, the European Union published ordinance EU 2020/741, establishing minimum requirements for water reuse in agriculture. The ordinance differentiates between several water quality classes. For the highest water quality class (Class A), the ordinance mandates analytical validation of the treatment performance of new water reuse treatment plants (WRTP) related to the removal of microbial indicators for viral, bacterial, and parasitic pathogens.
View Article and Find Full Text PDFThe pattern of cytokine profile in children received extracorporeal blood purification.
Int J Artif Organs
January 2025
Department of Paediatrics and Adolescent Medicine, Hong Kong Children's Hospital, Kowloon, Hong Kong.
We reported the cytokine profile in children <18 years old who received extracorporeal blood purification (EBP) for sepsis, rhabdomyolysis, hyperbilirubinaemia, acute respiratory distress syndrome or cytokine storm, and determined the factors affecting the cytokine removal kinetics. Plasma levels of 38 types of cytokine/chemokine were measured at pre-EBP, 12 and 24 h after initiating EBP. Altogether there were 11 eligible episodes admitted between April 2021 and December 2023.
View Article and Find Full Text PDFThe Complete Inpatient Record Using Comprehensive Electronic Data (CIRCE) project: A team-based approach to clinically validated, research-ready electronic health record data.
Learn Health Syst
January 2025
Department of Biostatistics, Epidemiology and Informatics University of Pennsylvania Perelman School of Medicine Philadelphia Pennsylvania USA.
Introduction: The rapid adoption of electronic health record (EHR) systems has resulted in extensive archives of data relevant to clinical research, hospital operations, and the development of learning health systems. However, EHR data are not frequently available, cleaned, standardized, validated, and ready for use by stakeholders. We describe an in-progress effort to overcome these challenges with cooperative, systematic data extraction and validation.
View Article and Find Full Text PDFBarriers to Research for Academic Otologists/Neurotologists in the United States.
Otol Neurotol
February 2025
Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins Hospital, Baltimore, MD.
Objective: The physician-scientist workforce is shrinking in the United States. Academic otologists/neurotologists face a diverse set of barriers to successful careers. We aimed to characterize the factors affecting contemporary otology/neurotology surgeon-scientists.
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