AI Article Synopsis
- The study examined how the risk of post-covid symptoms differed between the first wave (March-May 2020) and the second wave (September-November 2020) of the pandemic in France, focusing on data from a national population-based cohort.
- Results showed a higher risk of 14.6% for post-covid symptoms during the first wave compared to 7.0% in the second wave, indicating an increased adjusted risk ratio of 1.36.
- Factors such as baseline physical and mental conditions, the number of acute symptoms, and educational level influenced the risk, with women also showing higher vulnerability during the first wave.
Article Abstract
It is unclear how the risk of post-COVID symptoms evolved during the pandemic, especially before the spread of Severe Acute Respiratory Syndrome Coronavirus 2 variants and the availability of vaccines. We used modified Poisson regressions to compare the risk of six-month post-COVID symptoms and their associated risk factors according to the period of first acute COVID: during the French first (March-May 2020) or second (September-November 2020) wave. Nonresponse weights and multiple imputation were used to handle missing data. Among participants aged 15 years or older in a national population-based cohort, the risk of post-COVID symptoms was 14.6% (95% confidence interval [CI], 13.9%-15.3%) in March-May 2020, vs 7.0% (95% CI, 6.3%-7.7%) in September-November 2020 (adjusted relative risk [RR], 1.36; 95% CI, 1.20-1.55). For both periods, the risk was higher in the presence of baseline physical condition(s), and it increased with the number of acute symptoms. During the first wave, the risk was also higher for women, in the presence of baseline mental condition(s), and it varied with educational level. In France in 2020, the risk of six-month post-COVID symptoms was higher during the first than the second wave. This difference was observed before the spread of variants and the availability of vaccines.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11735949 | PMC |
| http://dx.doi.org/10.1093/aje/kwae174 | DOI Listing |
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