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Efficacy and Safety of Bintrafusp Alfa, a Bifunctional Fusion Protein Targeting Transforming Growth Factor-β and Programmed Death-Ligand 1, Plus Chemotherapy in Patients With Stage IV NSCLC.
JTO Clin Res Rep
January 2025
Institut de Cancérologie de l'Ouest, 44805 Saint-Herblain, France.
Introduction: In a phase 1 study, bintrafusp alfa was found to have an encouraging clinical activity in patients with previously treated advanced NSCLC. This study evaluated the safety and efficacy of bintrafusp alfa with chemotherapy in patients with stage IV NSCLC regardless of the programmed death-ligand 1 (PD-L1) expression status.
Methods: In this open-label, phase 1b/2 study (NCT03840915), eligible patients were assigned to one of four cohorts.
No Need for Subacromial Decompression in Responders to Specific Exercise Treatment - A 10-year follow-up of a Randomized Clinical Trial.
J Shoulder Elbow Surg
December 2024
Department of Medicine, Health and Caring Sciences, Division of Physiotherapy, Linköping University, Sweden.
Background: Subacromial pain is a common and disabling condition with multifactorial aetiology. Increasing evidence supports exercises as first-line treatment and need of surgery is debated. Long-term follow-ups after surgical- and non-surgical treatment are scarce.
View Article and Find Full Text PDFAgronomic biofortification of genetically biofortified wheat genotypes with zinc, selenium, iodine, and iron under field conditions.
Front Plant Sci
December 2024
Faculty of Engineering and Natural Sciences, Sabanci University Orta, Istanbul, ;Türkiye.
Inherently low concentrations of zinc (Zn), iron (Fe), iodine (I), and selenium (Se) in wheat ( L.) grains represent a major cause of micronutrient malnutrition (hidden hunger) in human populations. Genetic biofortification represents a highly useful solution to this problem.
View Article and Find Full Text PDF[Research progress on pollen monitoring and pollen allergenicity of ragweed].
Zhonghua Yu Fang Yi Xue Za Zhi
December 2024
Department of Allergy, ShengJing Hospital of China Medical Universty, Shenyang110000, China.
Ragweed, as an exotic invasive species, which is one of the most important allergens for hay fever, has been invading China for more than 80 years. The increasing number of people with hay fever makes effective treatment, as well as the prevention and control of pollen transmission critical. This article delves into a comprehensive research summary focusing on the allergenic properties of ragweed pollen, its pathogenic characteristics, epidemiological patterns, monitoring and control measures, as well as concentrated management approaches.
View Article and Find Full Text PDFSociety of Family Planning Clinical Recommendation: Medication management for early pregnancy loss.
Contraception
December 2024
Planned Parenthood South Atlantic, Raleigh, NC, USA and McLeod Regional Medical Center, Florence, SC, USA; University of Washington Department of Obstetrics and Gynecology, 1959 NE Pacific St, Box 356460, Seattle, WA 98005, USA; Pegasus Health Justice Center, Dallas, TX, 75207, USA; Washington University, St. Louis, MO, USA.
Early pregnancy loss (EPL), also known as miscarriage or spontaneous abortion, makes up 15-20% of all clinically recognized pregnancies. EPL is a broad term that includes intrauterine pregnancies (IUPs) with findings that suggest the pregnancy may not progress or definitely will not progress; pregnancies with a gestational sac (GS) in the lower endometrial cavity or endocervical canal in the process of expulsion; residual pregnancy tissue or persistent GS; and complete passage of the GS without residual tissue. This document addresses medication management of EPL in which the complete passage of the GS has not yet occurred, including pregnancies concerning for and diagnostic of EPL (sometimes called "missed abortion") and EPL in progress.
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