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Bunionectomy as an Acute Postoperative Pain Model: Overview of Common Experimental Methods, and Insights from Past Clinical Trials.
J Pain Res
December 2024
Chariton Pharmaceuticals, Cambridge, MA, USA.
To obtain broad regulatory approval for a new analgesic agent in acute postoperative pain, US and European regulatory authorities require pivotal studies in both hard (bony) tissue pain and soft tissue pain. Bunionectomy is by far the most common hard tissue pivotal trial model, in spite of the fact that the model has limited relevance to clinicians prescribing pain drugs (pain from bunionectomy is not extreme or long-lasting, and is adequately treated by existing drugs). The authors outline the experimental characteristics that make bunionectomy an appealing study model for researchers despite its lack of clinical relevance compared to larger surgeries.
View Article and Find Full Text PDFUsing cerebrospinal fluid biomarkers to diagnose Alzheimer's disease: an Australian perspective.
Front Psychiatry
December 2024
National Dementia Diagnostics Laboratory, The Florey Institute, The University of Melbourne, Melbourne, VIC, Australia.
Cerebrospinal fluid (CSF) biomarkers are currently the only clinically validated biofluid diagnostic test for Alzheimer's Disease (AD) available in Australia. Testing of CSF biomarkers via lumbar puncture (LP), including quantification of amyloid-β peptide, total tau protein, and phosphorylated tau, can give insight into underlying pathophysiological changes and provide greater certainty in confirming or excluding the presence of Alzheimer's disease changes compared to standard clinical and radiological assessments. Despite CSF analysis being a safe and cost-effective diagnostic method, the use of CSF biomarkers in the evaluation of potential AD remains limited in Australian clinical practice due to a variety of factors, including regional access challenges, concerns over the perceived invasiveness of LP and a lack of confidence among clinicians in interpreting the results.
View Article and Find Full Text PDFHow the master's level is implemented in internships within master's programmes - exploring the views of students, clinicians, and educators in midwifery and public health nursing.
BMC Med Educ
December 2024
Faculty of Health Sciences, Department of Nursing and Health Promotion, OsloMet Metropolitan University, Oslo, Norway.
In the course of worldwide attempts at the academisation of professional education and the Bologna process, nursing education has become both bachelor's and master's programmes at colleges, polytechnics, and universities.We investigated how a master's level in internships is conceptionalised by the involved parties. Our focus was on Norwegian master's education programmes in two different health professions, midwifery and public health nursing.
View Article and Find Full Text PDFUnmasking culprits: novel analysis identifies complement factors as potential therapeutic targets to mitigate inflammation during children's heart surgery.
Eur J Med Res
December 2024
Division of Cardiac Surgery, IWK Children's Heart CentreDivision of Cardiac Surgery, Dalhousie University, Halifax, Canada.
Background: Cardiopulmonary bypass (CPB) causes systemic inflammation during pediatric cardiac surgery, which can contribute to post-operative organ dysfunction and prolonged recovery. This study aims to identify key inflammatory mediators related to this clinically significant immunologic response.
Methods: Pediatric patients were enrolled in a single-arm prospective clinical study (NCT05154864) and received standard cardiac operation, CPB and subzero-balance ultrafiltration.
Benefits and challenges of the integration of haptics-enhanced virtual reality training within dental curricula.
J Dent Educ
December 2024
Faculty of Health & Life Sciences, Institute of Life Course and Medical Sciences, School of Dentistry, University of Liverpool, Liverpool, UK.
Background: Haptics-enhanced virtual reality (VR-haptic) simulation in dental education has evolved considerably during the past decade, representing a promising resource of simulation-based training opportunities to support conventional practice. We aim to summarize current literature on the applications of VR-haptics in learning, practicing, and teaching dental education.
Methods: A literature search was performed using PubMed, focusing on research articles published between January 2010 and January 2024.
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