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Sleep-disordered breathing and cardiometabolic and inflammatory markers in children with overweight/obesity: The role of cardiorespiratory fitness.
Pediatr Obes
January 2025
Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain.
Objectives: To investigate the association of sleep-disordered breathing (SDB) severity with cardiometabolic and inflammatory markers independently of the adiposity levels; and to explore the role of cardiorespiratory fitness in these associations in children with overweight/obesity.
Methods: A total of 109 children aged 8-11 years with overweight/obesity were included in this cross-sectional study. SDB was assessed using a scale of the reduce version of the Paediatric Sleep Questionnaire.
Proteins Involved in Endothelial Function and Inflammation Are Implicated in Cerebral Small Vessel Disease.
Stroke
January 2025
Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, United Kingdom. (Z.S., E.L.H., H.S.M.).
Background: Endothelial dysfunction and inflammation have been implicated in the pathophysiology of cerebral small vessel disease (SVD). However, whether they are causal, and if so which components of the pathways represent potential treatment targets, remains uncertain.
Methods: Two-sample Mendelian randomization (MR) was used to test the association between the circulating abundance of 996 proteins involved in endothelial dysfunction and inflammation and SVD.
Carotid bodies mediate glial cell activation and neuroinflammation in the NTS following long-term intermittent hypoxia: role in cardiorespiratory dysfunction.
Am J Physiol Lung Cell Mol Physiol
January 2025
Instituto de Ciencias Biomédicas, Universidad Autónoma de Chile, Santiago, Chile.
Chronic intermittent hypoxia (CIH), the main feature of obstructive sleep apnea, heightened chemosensory discharges of the carotid body (CB), which contributes to potentiate the ventilatory hypoxic response and elicits hypertension. We aimed to determine: 1) whether the persistence of cardiorespiratory alterations found in long-term CIH depend on the inputs from the CB and, 2) in what extension the activation of glial cells and neuroinflammation in the caudal region of the nucleus of the Solitary Tract (NTS) requires functional CB chemosensory activity. To evaluate these hypotheses, we exposed male mice to CIH for 60 days.
View Article and Find Full Text PDFEvaluation of Dynamic Respiratory Muscle Strength, Physical Fitness, and Physical Activity in Children with Asthma and Healthy Peers.
Healthcare (Basel)
December 2024
Department of Pediatric Allergy, Hacettepe University School of Medicine, 06230 Ankara, Turkey.
: Systemic inflammation, attacks, deterioration of thoracic region mechanics, medications used, and decreased physical activity level (PAL) and fitness negatively may affect respiratory muscle strength. The primary aim of this study was to evaluate dynamic inspiratory muscle strength (S-index), PAL, and physical fitness in children with asthma compared to healthy peers. The secondary aim of this study was to investigate the relationships between S-index and peak inspiratory flow (PIF) values and functional parameters in childhood asthma.
View Article and Find Full Text PDFHazardous alcohol use and cardiometabolic risk among firefighters.
Alcohol Clin Exp Res (Hoboken)
January 2025
Neuromuscular and Occupational Performance Laboratory, Department of Kinesiology & Sport Management, Texas Tech University, Lubbock, Texas, USA.
Article Synopsis
- Firefighters who misuse alcohol (high AUDIT-C scores) are at greater risk for various cardiometabolic issues, including higher cholesterol and blood pressure levels compared to those with low alcohol use.
- Mental health conditions like PTSD, depression, and anxiety may influence this risk, affecting how alcohol misuse relates to blood pressure and lipid levels.
- Overall, understanding these relationships is crucial since they could impact the firefighters' readiness for duty and overall health.
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