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Targeting the brain's glymphatic pathway: a novel therapeutic approach for cerebral small vessel disease.
Neural Regen Res
December 2024
Department of Neurology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Cerebral small vessel disease encompasses a group of neurological disorders characterized by injury to small blood vessels, often leading to stroke and dementia. Due to its diverse etiologies and complex pathological mechanisms, preventing and treating cerebral small vessel vasculopathy is challenging. Recent studies have shown that the glymphatic system plays a crucial role in interstitial solute clearance and the maintenance of brain homeostasis.
View Article and Find Full Text PDFDTI-ALPS index as a predictor of cognitive decline over 1 year.
Neuroradiology
December 2024
Department of Psychiatry, Chungbuk National University Hospital, 1 Sunhwan-ro, Cheongju, 28644, Republic of Korea.
Purpose: Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and impaired daily functioning. The glymphatic system removes neurotoxic waste, including amyloid-beta (Aβ), an important factor in AD pathogenesis. This study used the Diffusion Tensor Imaging Analysis Along the Perivascular Space (DTI-ALPS) index, which reflects glymphatic function, to explore its relationship with cognitive decline in patients with probable AD.
View Article and Find Full Text PDFInfarctive encephalopathy in zoo-housed gibbons in North America.
Vet Pathol
December 2024
Cornell University, Ithaca, NY.
Progressive neurologic signs without a known underlying etiology have been observed in managed gibbon populations housed at institutions in North America. In 2018, the Gibbon Species Survival Plan initiated a veterinary survey to evaluate clinical histories among gibbons displaying neurologic signs. The clinical results of this survey as well as the results of a centralized histologic review of brain samples from 5 species of managed gibbons displaying neurologic signs are outlined here.
View Article and Find Full Text PDFNeuropathology of trisomy 21 mosaicism in a case with early-onset dementia.
Alzheimers Dement
December 2024
Department of Pathology and Laboratory Medicine, University of California, Irvine, Irvine, California, USA.
Introduction: This study investigated the impact of trisomy 21 mosaicism (mT21) on Alzheimer's disease (AD) neuropathology in a well-characterized clinical case described by Ringman et al.
Methods: We describe AD neuropathology in mT21 including amyloid beta, phosphorylated tau, astrogliosis, microgliosis, α-synuclein, and TAR DNA-binding protein 43 (TDP-43) in cerebral cortex, hippocampal subregions, and amygdala using immunohistochemistry.
Results: We observed high AD neuropathologic change with a score of A3B3C3.
The role and mechanism of Aβ clearance dysfunction in the glymphatic system in Alzheimer's disease comorbidity.
Front Neurol
November 2024
Department of Neurology, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
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