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STIM1: A new player in nuclear dynamics? Lessons learnt from tubular aggregate myopathy. | LitMetric

STIM1: A new player in nuclear dynamics? Lessons learnt from tubular aggregate myopathy.

Cell Calcium

Department of Drug Science and Technology, University of Turin, Turin, Italy. Electronic address:

Published: November 2024

AI Article Synopsis

  • Recent studies show that STIM1, important for calcium entry in cells, can move to the nucleus.
  • In the nucleus, STIM1 plays a role in managing calcium levels and aiding DNA repair.
  • These discoveries suggest STIM1 might influence various health issues and diseases more than previously thought.

Article Abstract

Two recent papers have highlighted that STIM1, a key component of Store-operated Ca2+-entry, is able to translocate to the nucleus and participate in nuclear Ca-handling and in DNA repair. These finding opens new avenues on the role that this Ca-sensing protein may have in health and disease.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ceca.2024.102926DOI Listing

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