AI Article Synopsis
- The mitochondrial unfolded protein response (UPR) helps protect cells from stress by maintaining protein balance, especially during mitochondrial stress.
- This response is connected to cardiovascular diseases, highlighting its importance in heart health.
- The review discusses UPR's mechanisms in mammals and suggests future research directions for UPR-targeted therapies in treating cardiovascular conditions.
Article Abstract
The mitochondrial unfolded protein response (UPR) is a cytoprotective response in response to cellular stress that is activated in response to mitochondrial stress to maintain intra-protein homeostasis, thereby protecting the cell from a variety of stimuli. The activation of this response has been linked to cardiovascular diseases. Here, we reviewed the current understanding of UPR and discussed its specific molecular mechanism, mainly in mammals, as well as addressing its protective role against cardiovascular diseases, so as to provide direction for further research on UPR and therapies targeting cardiovascular diseases in the future.
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| http://dx.doi.org/10.1016/j.biopha.2024.116989 | DOI Listing |
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