Palladium-catalyzed reaction of indolines with 1-acyl-2,3-dihydro-1-pyrroles or 1-acyl-2,5-dihydro-1-pyrroles in air produces -alkylated indoles. A combination of Pd(CHCN)Cl and dppf effectively catalyzes the reaction of 1-acyl-2,3-dihydro-1-pyrroles, and the combination of Pd(CHCN)Cl and dcypf is more effective for the reaction of 1-acyl-2,5-dihydro-1-pyrroles. The method has a wide scope of substrates and shows good compatibility of functional groups.
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| http://dx.doi.org/10.1021/acs.joc.4c00855 | DOI Listing |
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