Synthesis of Nonclassical Heteroaryl C-Glycosides via Decarboxylative C-H Glycosylation.

J Org Chem

Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, No. 17, Third Section, South Renmin Road, Chengdu 610041, Sichuan, P. R. China.

Published: July 2024

A photoredox-promoted decarboxylative C-H glycosylation for the synthesis of nonclassical heteroaryl C-glycosides is reported. This methodology is characterized by an exceedingly simple reaction system, high diastereoselectivity, and good functional group tolerance. Moreover, the operational procedure is simple, and the gram-scale reaction highlights the practical applicability of this protocol.

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http://dx.doi.org/10.1021/acs.joc.4c00868DOI Listing

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