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Acute Concurrent Exercise Improves Inhibitory Control Without Mediating the Role of Lactate: An Event-Related Potential Study.
Sports Med Open
January 2025
Department of Physical Education and Sport Sciences, National Taiwan Normal University, 162, Section 1, Heping E. Road, Taipei, 106, Taiwan.
Background: Concurrent exercise (CE), an emerging exercise modality characterized by sequential bouts of aerobic (AE) and resistance exercise (RE), has demonstrated acute benefits on executive functions (EFs) and neuroelectric P3 amplitude. However, the effect of acute CE on inhibitory control, a sub-component of EFs, and P3 amplitude remains inconclusive. Moreover, exploring the mechanisms underlying the effects of acute exercise on EFs contributes to scientific comprehension, with lactate recognized as a crucial candidate positively correlated with EFs.
View Article and Find Full Text PDFClinical Activity of Mitogen-Activated Protein Kinase Inhibitors in Patients With MAP2K1 (MEK1)-Mutated Metastatic Cancers.
JCO Precis Oncol
January 2025
McGill University Faculty of Medicine, Montréal, QC, Canada.
Purpose: MAP2K1/MEK1 mutations are potentially actionable drivers in cancer. MAP2K1 mutations have been functionally classified into three groups according to their dependency on upstream RAS/RAF signaling. However, the clinical efficacy of mitogen-activated protein kinase (MAPK) pathway inhibitors (MAPKi) for MAP2K1-mutant tumors is not well defined.
View Article and Find Full Text PDFRadiobiologically equivalent deformable dose mapping for re-irradiation Planning: Implementation, Robustness, and dosimetric benefits.
Radiother Oncol
January 2025
Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI 53226, United States. Electronic address:
Background: Re-irradiation in radiotherapy presents complexities that require dedicated tools to generate optimal re-treatment plans. This study presents a robust workflow that considers fractionation size, anatomical variations between treatments, and cumulative bias doses to improve the re-irradiation planning process.
Methods: The workflow was automated in MIM® Software and the Elekta© Monaco® treatment planning system.
The effects of volunteering on loneliness among lonely older adults: the HEAL-HOA dual randomised controlled trial.
Lancet Healthy Longev
January 2025
Department of Social Sciences and Policy Studies, The Education University of Hong Kong, Tai Po, Hong Kong Special Administrative Region, China.
Background: Previous randomised controlled trials have largely relied on self-reported volunteer work to assess the effects of volunteering and have rarely provided structured volunteering activities during the intervention period. The present study aimed to investigate the effects of social volunteering work over 12 months on loneliness among older adults during the COVID-19 pandemic.
Methods: A dual randomised controlled trial was done in Hong Kong to investigate the long-term effects of telephone-delivered psychosocial interventions by older Chinese volunteers who were screened as lonely, for older adult recipients who had low income, lived alone, felt lonely, and were digitally excluded.
Relationship Between Sedentary Lifestyle, Physical Activity and Stress in University Students and Their Life Habits: A Scoping Review with PRISMA Checklist (PRISMA-ScR).
Brain Sci
January 2025
Department of Psychology and Education, Pegaso Telematic University, 80143 Naples, Italy.
Unlabelled: The global prevalence of sedentary lifestyles and the associated health risks, such as cardiovascular, metabolic and mental issues, is an epidemic worldwide problem, particularly in the university population.
Background/objectives: University students are particularly vulnerable because of academic pressure and lifestyle changes. Despite the well-known benefits of physical activity in reducing mental stress and improving physical and mental well-being, the literature lacks effective interventions and standardized protocols for this population.
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