AI Article Synopsis
- Dinitrogen trioxide (N2O3) plays a role in S- and N-nitrosation of low-molecular weight compounds and proteins, influencing nitrating intermediates and nitrite-induced vasodilation in low oxygen conditions.
- Due to its very short half-life in biological systems, N2O3 is hard to detect using standard technologies; evidence for its formation comes from various methods like detecting nitrosated products and using kinetic, isotopic labeling, and spectroscopic analyses.
- The review will focus on how N2O3 is formed, its reactivity and breakdown in cells, the importance of where it acts within the cell, and its potential functions as a significant signaling molecule.
Article Abstract
Dinitrogen trioxide ( ) mediates low-molecular weight and protein S- and N-nitrosation, with recent reports suggesting a role in the formation of nitrating intermediates as well as in nitrite-dependent hypoxic vasodilatation. However, the reactivity of in biological systems results in an extremely short half-life that renders this molecule essentially undetectable by currently available technologies. As a result, evidence for formation derives from the detection of nitrosated products as well as from kinetic determinations, isotopic labeling studies, and spectroscopic analyses. This review will discuss mechanisms of formation, reactivity and decomposition, as well as address the role of sub-cellular localization as a key determinant of its actions. Finally, evidence will be discussed supporting different roles for as a biologically relevant signaling molecule.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11218869 | PMC |
| http://dx.doi.org/10.1016/j.rbc.2024.100026 | DOI Listing |
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Article Synopsis
- Dinitrogen trioxide (N2O3) plays a role in S- and N-nitrosation of low-molecular weight compounds and proteins, influencing nitrating intermediates and nitrite-induced vasodilation in low oxygen conditions.
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