Research Progress in the Field of Tumor Model Construction Using Bioprinting: A Review.

Int J Nanomedicine

Department of Orthopedics, the Fourth Affiliated Hospital of China Medical University, China Medical University, Shen Yang, 110032, People's Republic of China.

Published: July 2024

AI Article Synopsis

  • The emergence of tumor models has greatly improved the development of therapeutic drugs, but creating models that accurately replicate real tumor tissues is still a complex task.
  • Advances in bioprinting and tissue engineering have contributed to the creation of 3D tumor models, enhancing the accuracy of simulations for research purposes.
  • The article discusses the integration of these technologies, the challenges they face, and how 3D tumor models can effectively mimic the tumor microenvironment, paving the way for new cancer therapies.

Article Abstract

The development of therapeutic drugs and methods has been greatly facilitated by the emergence of tumor models. However, due to their inherent complexity, establishing a model that can fully replicate the tumor tissue situation remains extremely challenging. With the development of tissue engineering, the advancement of bioprinting technology has facilitated the upgrading of tumor models. This article focuses on the latest advancements in bioprinting, specifically highlighting the construction of 3D tumor models, and underscores the integration of these two technologies. Furthermore, it discusses the challenges and future directions of related techniques, while also emphasizing the effective recreation of the tumor microenvironment through the emergence of 3D tumor models that resemble in vitro organs, thereby accelerating the development of new anticancer therapies.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11217009PMC
http://dx.doi.org/10.2147/IJN.S460387DOI Listing

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