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http://dx.doi.org/10.1093/noajnl/vdae092 | DOI Listing |
Hum Genomics
December 2024
Department of Stomatology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Background: Oral squamous cell carcinoma (OSCC) is an aggressive malignancy with poor prognosis. Neutrophil infiltration has been associated with unfavorable outcomes in OSCC, but the underlying molecular mechanisms remain unclear.
Methods: This study integrated single-cell transcriptomics (scRNA-seq) with bulk RNA-seq data to analyze neutrophil infiltration patterns in OSCC and identify key gene modules using weighted gene co-expression network analysis (hdWGCNA).
J Nanobiotechnology
December 2024
Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, 410011, China.
Chemotherapy is still one of the major approaches in triple-negative breast cancer (TNBC) treatment. The development of new formulations for classic chemotherapeutic drugs remains interests in studies. Camptothecin (CPT) is powerful antitumor agents in TNBC treatment though its clinic applications are limited by its low water solubility and systemic toxicity.
View Article and Find Full Text PDFMol Cancer
December 2024
Department of Medical Oncology, Gastric Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province, 610041, China.
Immune checkpoint inhibitors (ICIs) have dramatically transformed the treatment landscape for various malignancies, achieving notable clinical outcomes across a wide range of indications. Despite these advances, resistance to immune checkpoint blockade (ICB) remains a critical clinical challenge, characterized by variable response rates and non-durable benefits. However, growing research into the complex intrinsic and extrinsic characteristics of tumors has advanced our understanding of the mechanisms behind ICI resistance, potentially improving treatment outcomes.
View Article and Find Full Text PDFBMC Plant Biol
December 2024
Rice Research Institute, Fujian Academy of Agricultural Sciences, Fuzhou, 350018, China.
Background: Rice is the main food crop for much of the population in China. Therefore, selecting and breeding new disease resistance and drought tolerance in rice is essential to ensure national food security. The utilization of heterosis has significantly enhanced rice productivity, yet many of the molecular mechanisms underlying this phenomenon remain largely unexplored.
View Article and Find Full Text PDFJ Agric Food Chem
December 2024
State Key Laboratory for Crop Stress Resistance and High-Efficiency Production and College of Life Sciences, Northwest A&F University, Yangling, Shaanxi 712100, China.
f. sp. () secretes a plethora of cell wall-degrading enzymes (CWDEs) to facilitate fungal invasion during infection.
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