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Diffusion tensor imaging for detecting biomarkers of idiopathic epilepsy in dogs.
Front Vet Sci
January 2025
Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada.
Idiopathic epilepsy (IE) is the most common neurological disease in dogs. Approximately 1/3 of dogs with IE are resistant to anti-seizure medications (ASMs). Because the diagnosis of IE is largely based on the exclusion of other diseases, it would be beneficial to indicate an IE biomarker to better understand, diagnose, and treat this disease.
View Article and Find Full Text PDFImpact of lifetime antiepileptic drug history on cenobamate efficacy in adults with focal epilepsy.
Seizure
December 2024
Epilepsy Center, Medical Center, University of Freiburg, Breisacher Str. 64, 79106 Freiburg im Breisgau, Germany.
Purpose: To evaluate the efficacy of cenobamate (CNB) in adults with focal epilepsy based on the number of previous lifetime antiseizure medications (ASMs).
Methods: Twenty patients receiving add-on treatment with CNB with <6 lifetime ASMs were retrospectively compared to 20 Patients with >10 ASMs and approximately the same age. Efficacy was assessed at 3, 6, and 12 months following CNB initiation.
Improving the resolution of solar energy potential maps derived from global DSMs for rooftop solar panel placement using deep learning.
Heliyon
January 2025
Faculty of Civil Engineering and Transportation, University of Isfahan, Isfahan, Iran.
This study focuses on generating high-resolution annual solar energy potential maps (ASMs) using global Digital Elevation Models (DEMs) to aid in solar panel placement, especially in urban areas. A framework was developed to enhance the resolution of these maps. Initially, the accuracy of ASMs derived from various DEMs was compared with LiDAR-derived ASMs.
View Article and Find Full Text PDFPost-marketing safety of antiseizure medications: Focus on serious adverse effects including drug reaction with eosinophilia and systemic symptoms (DRESS).
Seizure
January 2025
Department of Pharmacy Practice, Auburn University Harrison College of Pharmacy, Auburn, AL 36049, United States.
Purpose: On November 28, 2023, the U.S. FDA issued a Drug Safety Communication, warning that antiseizure medications (ASMs) levetiracetam and clobazam can cause a rare but serious reaction, drug reaction with eosinophilia and systemic symptoms (DRESS).
View Article and Find Full Text PDFGlymphatic system dysfunction in epilepsy related to focal cortical dysplasia and its relationship with antiseizure medication response.
Seizure
December 2024
Department of Neurology, Epilepsy Center, University of Pittsburgh Medical Center, Pittsburgh, PA, United States.
Purpose: Glymphatic function has not been explored in patients with focal cortical dysplasia (FCD)-related epilepsy. This study aimed to investigate the glymphatic system's involvement in these patients and to evaluate its correlation with response patterns to different antiseizure medications (ASMs) using diffusion tensor imaging along the perivascular space (DTI-ALPS).
Methods: Fifty-two patients with FCD-related epilepsy (10 with drug-responsive epilepsy and 42 with drug-resistant epilepsy) and 24 healthy controls (HC) were included.
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