As one of the most powerful trifluoromethylation reagents, (trifluoromethyl)trimethylsilane (TMSCF) has been widely used for the synthesis of fluorine-containing molecules. However, to the best of our knowledge, the simultaneous incorporation of both TMS- and CF- groups of this reagent onto the same carbon of the products has not been realized. Herein, we report an unprecedented SmI/Sm promoted deoxygenative difunctionalization of amides with TMSCF, in which both silyl and trifluoromethyl groups are incorporated into the final product, yielding α-silyl-α-trifluoromethyl amines with high efficiency. Notably, the silyl group could be further transformed into other functional groups, providing a new method for the synthesis of α-quaternary α-CF-amines.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/jacs.4c04760 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Brachial Plexus Birth Injury: Treatment and Interventions.
Plast Surg (Oakv)
January 2025
Division of Plastic and Reconstructive Surgery, Saint Louis University Hospital, St. Louis, MO, USA.
Brachial plexus birth injury (BPBI) is a condition affecting newborns and involves damage to the nerve fibers compromising the brachial plexus during birth. Although most newborns recover spontaneously, a large subset require surgery to regain function, and others will have permanent disability despite intervention. Deciding when to pursue surgical intervention remains a challenge for clinicians treating BPBI.
View Article and Find Full Text PDFFamily physicians' perspectives on outcomes, processes, and policies in dementia care.
Health Aff Sch
January 2025
Department of Family Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, United States.
The rapid rise in numbers of people living with Alzheimer's disease and related disorders (ADRD) poses major challenges to health systems and policy. Although primary care clinicians provide ongoing medical care for 80% of affected individuals, they face persistent barriers to providing high-quality dementia care. We conducted qualitative interviews with family physicians ( = 20) to understand what core outcomes they consider most important and what care processes and systems and policy strategies they propose to achieve them.
View Article and Find Full Text PDFDisparate Use of Diagnostic Modalities for Patients With Limited English Proficiency and Neurologic Disorders.
Neurol Clin Pract
April 2025
Department of Neurology (AS), Massachusetts General Hospital, Harvard Medical School, Boston; Department of Public Health Sciences (RBAB), University of North Carolina at Charlotte; Disparities Research Unit, Department of Medicine, Massachusetts General Hospital; Department of Psychiatry, Harvard Medical School; Harvard Medical School (DH, SW), Boston; and City University of New York at Hunter College (DH, SW).
Background And Objectives: Limited English proficiency (LEP) impairs health access-including outpatient specialty care-and quality care, i.e., inappropriate use of diagnostic tests.
View Article and Find Full Text PDFTranslation and assessment of encultured meaning of the Multi-Dimensional Scale of Perceived Social Support in Diné bizaad (Navajo) using community-based participatory action research methods.
Rural Remote Health
January 2025
Indiana University School of Medicine, Indianapolis, Indiana, USA.
Introduction: Perceived social support is a psychological construct that is used to describe the 'perception of adequacy' of the support being provided by a person's social network. Higher perceived social support has been linked to multiple benefits across numerous studies over the past several decades and among multiple populations. The Multidimensional Scale of Perceived Social Support (MSPSS) is a 12-item scale to assess the construct of perceived social support.
View Article and Find Full Text PDFDecoding the elite soccer player's psychological profile.
Proc Natl Acad Sci U S A
January 2025
Center for Psychiatry Research and Center for Cognitive and Computational Neuropsychiatry, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm 17177, Sweden.
Soccer is arguably the most widely followed sport worldwide, and many dream of becoming soccer players. However, only a few manage to achieve this dream, which has cast a significant spotlight on elite soccer players who possess exceptional skills to rise above the rest. Originally, such attention was focused on their great physical abilities.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!