AI Article Synopsis
- * Genetic analysis revealed that these viruses belong to genotype B3.2 of clade 2.3.4.4b, which originated in North America but has now reached South America.
- * The viruses have mutations that suggest a growing ability to infect mammalian hosts, indicating an ongoing evolution that could increase their zoonotic potential.
Article Abstract
Clade 2.3.4.4b highly pathogenic avian influenza (HPAI) H5N1 virus was detected in the South American sea lions found dead in Santa Catarina, Brazil, in October 2023. Whole genome sequencing and comparative phylogenetic analysis were conducted to investigate the origin, genetic diversity, and zoonotic potentials of the H5N1 viruses. The H5N1 viruses belonged to the genotype B3.2 of clade 2.3.4.4b H5N1 virus, which was identified in North America and disseminated to South America. They have acquired new amino acid substitutions related to mammalian host affinity. Our study provides insights into the genetic landscape of HPAI H5N1 viruses in Brazil, highlighting the continuous evolutionary processes contributing to their possible adaptation to mammalian hosts.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11221036 | PMC |
| http://dx.doi.org/10.1186/s12917-024-04137-1 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Marked neurotropism and potential adaptation of H5N1 clade 2.3.4.4.b virus in naturally infected domestic cats.
Emerg Microbes Infect
December 2025
Department of Infectious Diseases and Microbiology, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
In April 2024, ten cats died in a rural South Dakota (SD) residence, showing respiratory and neurological symptoms. Necropsy and laboratory testing of two cats confirmed H5N1 clade 2.3.
View Article and Find Full Text PDFMass Mortality in Terns and Gulls Associated with Highly Pathogenic Avian Influenza Viruses in Caspian Sea, Kazakhstan.
Viruses
October 2024
Research Institute of Wildlife Ecology, University of Veterinary Medicine Vienna, 1160 Vienna, Austria.
Mass mortality in Caspian terns (), Pallas's gulls (), and Caspian gulls () was recorded on the northeastern shores of the Caspian Sea in June 2022. More than 5000 gulls and terns died due to the outbreak. The outbreak was investigated in the field, and representative numbers of samples were collected and analyzed using pathological, virological, and molecular methods.
View Article and Find Full Text PDFReassortants of the Highly Pathogenic Influenza Virus A/H5N1 Causing Mass Swan Mortality in Kazakhstan from 2023 to 2024.
Animals (Basel)
November 2024
Research Institute for Biological Safety Problems (RIBSP), Gvardeiskiy 080409, Kazakhstan.
In the winter of 2023/2024, the mass death of swans was observed on Lake Karakol on the eastern coast of the Caspian Sea. From 21 December 2023 to 25 January 2024, 1132 swan corpses (, ) were collected and disposed of on the coast by veterinary services and ecologists. Biological samples were collected from 18 birds for analysis at different dates of the epizootic.
View Article and Find Full Text PDFAvian influenza A (H5N1) virus in dairy cattle: origin, evolution, and cross-species transmission.
mBio
December 2024
Department of Disease Intervention and Prevention, Texas Biomedical Research Institute, San Antonio, Texas, USA.
Since the emergence of highly pathogenic avian influenza virus (HPAIV) H5N1 of clade 2.3.4.
View Article and Find Full Text PDFRecent Occurrence, Diversity, and Candidate Vaccine Virus Selection for Pandemic H5N1: Alert Is in the Air.
Vaccines (Basel)
September 2024
Centro BioIndustrial, Instituto Butantan and Fundação Butantan, São Paulo 05503-900, SP, Brazil.
Article Synopsis
- * The virus has evolved from the A/Goose/Guangdong/1/96 lineage, adapting to infect other species, including potential mammal-to-mammal transmission.
- * Public health agencies view H5N1 as a significant pandemic threat, prompting research into hemagglutinin sequences to aid in developing effective vaccines for potential outbreaks.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!