Although validated and reliable psychophysical tests of olfactory function are available, an easy-to-use and feasible test has yet to be developed. This study aimed to design a digital odour identification test, evaluate its validity, assess its reliability, establish a normative curve, and explore the impact of demographic factors. The odour identification test was presented with the Multiscent-20, a hand-held, tablet-like digital scent device that features an integrated odour digital delivery system. The identification performance on the 20 odours was assessed using item response theory (IRT). The normative curve was established by administering the test to a large sample of participants (n = 1299). The mean identification score was 17.5 (SD = 2.1). The two-parameter logistic IRT model provided the best fit, revealing variation in item discrimination and difficulty parameters. Educational attainment influenced performance, with primary education associated with lower scores. Additionally, sex was not found to be associated with performance. This study provides initial evidence supporting the validity and reliability of use of the Multiscent-20 as a digital odour identification test. The test's automation and portability enable the standardized delivery of olfactory stimuli and efficient automatic recording and scoring of responses.
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http://dx.doi.org/10.1038/s41598-024-65915-3 | DOI Listing |
Alzheimers Dement
December 2024
Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
Background: Olfactory deficits are predictive of cognitive decline and dementia. Previous studies have linked brain magnetic resonance imaging markers of neurodegeneration to olfactory deficits in aging; however, these studies analyzed cross-sectional data for markers, olfaction, or both. Furthermore, potential cerebrovascular contributions to understanding why olfactory deficits predict dementia remain unexplored.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Columbia University Irving Medical Center, New York, NY, USA.
Background: Inexpensive, non-invasive tests may improve the identification of persons at increased risk for cognitive decline and dementia. We compared impairment in odor identification and global cognition with neuro-imaging biomarkers to predict cognitive decline and dementia in the population-based Mayo Clinic Study of Aging (MCSA).
Method: At the 2008 assessment, 647 participants who were ≥ 55 years old with at least one follow-up had the following procedures: modified Blessed Information-Memory-Concentration Test (BIMCT), 12-item Brief Smell Identification Test (BSIT), brain magnetic resonance imaging (MRI), and Positron Emission Tomography (PET) amyloid imaging with 11C-Pittsburgh compound B (11C-PiB).
Alzheimers Dement
December 2024
Columbia University Irving Medical Center, New York, NY, USA.
Background: Early detection of dementia and cognitive impairment is recommended for persons 65 years and older during wellness primary care visits. The importance of early detection has increased with the availability of new treatments for early Alzheimer's disease (AD). However, there is no clear approach for early detection in primary care.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Background: Few population-based studies have comprehensively examined the association between impaired olfactory identification and the prevalence of mild cognitive impairment (MCI) and regional brain volumes in a general older population without dementia.
Method: A total of 1,292 participants without dementia aged 65 years or older underwent a Japanese Pocket Smell Test, an assessment of cognitive function, and a brain magnetic resonance imaging scanning in 2017-2018. Impaired olfactory identification was defined as incorrect identification of three or more odors in the Japanese Pocket Smell Test, where participants sniffed eight microencapsulated odors (strawberries, chocolate, mint, smoke, soap, grapes, onions, and roses) and selected the corresponding odor from four choices for each odor.
Alzheimers Dement
December 2024
Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Background: Olfactory impairment appears early in the course of Alzheimer's Disease (AD) and may serve as a non-invasive early marker of AD. Few studies have examined the association between olfaction and blood biomarkers of AD neuropathology in large, diverse, community-based populations. Blood levels of amyloid-beta (Aβ and Aβ), phosphorylated-tau (p-tau) forms, glial fibrillary acidic protein (GFAP), and neurofilament-light chain (NfL) appear to reliably reflect corresponding brain neuropathologies and neurodegeneration.
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