AI Article Synopsis
- Synthetic lethality is emerging as a key strategy for anticancer therapies, expanding beyond just PARP inhibitors for BRCA1/2-defective tumors.
- New molecular targets, particularly in DNA damage response, are quickly progressing to clinical trials, showcasing the growing interest in synthetic lethal approaches.
- The article highlights the latest developments in synthetic lethal targets, discusses their design and therapeutic strategies, and ends with an exploration of the challenges and opportunities for future research in this area.
Article Abstract
In recent years, synthetic lethality has been recognized as a solid paradigm for anticancer therapies. The discovery of a growing number of synthetic lethal targets has led to a significant expansion in the use of synthetic lethality, far beyond poly(ADP-ribose) polymerase inhibitors used to treat BRCA1/2-defective tumors. In particular, molecular targets within DNA damage response have provided a source of inhibitors that have rapidly reached clinical trials. This Perspective focuses on the most recent progress in synthetic lethal targets and their inhibitors, within and beyond the DNA damage response, describing their design and associated therapeutic strategies. We will conclude by discussing the current challenges and new opportunities for this promising field of research, to stimulate discussion in the medicinal chemistry community, allowing the investigation of synthetic lethality to reach its full potential.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11284803 | PMC |
| http://dx.doi.org/10.1021/acs.jmedchem.4c00113 | DOI Listing |
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