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An interdisciplinary e-learning intervention for professionals working with breast cancer survivors and chronic pain: a realist evaluation.
Disabil Rehabil
December 2024
Department of Public Health and Primary Care, Ghent University, Ghent, Belgium.
Purpose: Chronic pain is prevalent among breast cancer survivors. Bio-psychosocial factors interplay in its exacerbation and maintenance. Therefore, prevention and treatment require an interdisciplinary response and the integration of various approaches.
View Article and Find Full Text PDFA contemporary review of the management strategies for sickle cell disease related ischaemic and stuttering priapism.
Int J Impot Res
December 2024
Department of Urology, Guy's & St Thomas' Hospital, London, UK.
Sickle cell disease is one of the most common autosomal recessive genetic disorders with 23% and over 70% of men with this condition, experiencing episodes of ischaemic priapism and stuttering priapism, respectively, with potentially severe consequences. The effective prevention of sickle cell disease induced ischaemic priapism and stuttering priapism requires a multidisciplinary and multimodal approach. A search of the English literature was performed utilising Pubmed® and Google Scholar to identify publications on contemporary and novel treatment options, with their associated treatment outcomes if available, that are utilised to prevent stuttering priapism episodes and hence a fulminant ischaemic priapism.
View Article and Find Full Text PDFScreening and identification of antimicrobial peptides from the gut microbiome of cockroach Blattella germanica.
Microbiome
December 2024
MOE Key Laboratory of Bio-Intelligent Manufacturing, School of Bioengineering, Dalian University of Technology, Dalian, Liaoning, 116024, China.
Article Synopsis
- * Researchers identified and validated an AMP, named AMP1, which has broad-spectrum antibacterial activity and minimal toxicity to human cells, showing potential as a safer alternative to traditional antibiotics.
- * The study emphasizes the effective screening of natural AMPs and highlights AMP1's ability to affect bacterial cell wall synthesis and promote wound healing, suggesting it could be a viable option for clinical use.
Built-in selection or confounder bias? Dynamic Landmarking in matched propensity score analyses.
BMC Med Res Methodol
December 2024
German Diabetes Center, Leibniz Center for Diabetes Research, Institute for Biometrics and Epidemiology, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
Background: Propensity score matching has become a popular method for estimating causal treatment effects in non-randomized studies. However, for time-to-event outcomes, the estimation of hazard ratios based on propensity scores can be challenging if omitted or unobserved covariates are present. Not accounting for such covariates could lead to treatment estimates, differing from the estimate of interest.
View Article and Find Full Text PDFA mixed-methods study of patient and healthcare professional perceptions of care pathways for knee osteoarthritis.
BMC Prim Care
December 2024
Artros d.o.o, Tehnološki park 19, Ljubljana, 1000, Slovenia.
Background: This study aimed to address research gap concerning the perception of the care pathway for knee osteoarthritis (KOA) patients, focusing on both the patient and health professional perspectives in countries with inefficient health systems, such as Slovenia, by examining patient satisfaction with conservative treatment, assessing the perceptions of both patients and health professionals regarding the latter's involvement, and justifying the chosen KOA treatment approaches.
Methods: A mixed-methods approach was employed, combining quantitative surveys and qualitative interviews with KOA patients (n = 82) and healthcare professionals (n = 68).
Results: The care pathway for conservative KOA treatment in Slovenia begins with general practitioners (GPs), who conduct initial examinations, prescribe analgesics, and refer patients to radiologists and orthopaedic surgeons.
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