AI Article Synopsis
- The SARS-CoV-2 virus has significantly impacted human health and the global economy, emphasizing the need for effective detection methods.
- Researchers introduced a multilayered plasmonic nanotrap (MPNT) device that utilizes surface-enhanced Raman scattering (SERS) to identify single SARS-CoV-2 virus particles with high sensitivity.
- The MPNT device can detect the virus's N protein at extremely low concentrations (as low as 1.25 × 10^−12 g/mL) within just one minute, and its design allows for future use against various infectious viruses.
Article Abstract
The spread of the SARS-CoV-2 virus has had an unprecedented impact, both by posing a serious risk to human health and by amplifying the burden on the global economy. The rapid identification of the SARS-CoV-2 virus has been crucial to preventing and controlling the spread of SARS-CoV-2 infections. In this study, we propose a multilayered plasmonic nanotrap (MPNT) device for the rapid identification of single particles of SARS-CoV-2 virus in ultra-high sensitivity by surface-enhanced Raman scattering (SERS). The MPNT device is composed of arrays of concentric cylindrical cavities with Ag/SiO/Ag multilayers deposited on the top and at the bottom. By varying the diameter of the cylinders and the thickness of the multilayers, the resonant optical absorption and local electric field were optimized. The SERS enhancement factors of the proposed device are of the order of 10, which enable the rapid identification of SARS-CoV-2 N protein in concentrations as low as 1.25 × 10－12.5 × 10 g mL within 1 min. The developed MPNT SERS device provides a label-free and rapid detection platform for SARS-CoV-2 virus. The general nature of the device makes it equally suitable to detect other infectious viruses.
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| http://dx.doi.org/10.1016/j.talanta.2024.126494 | DOI Listing |
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