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Comparison of the diagnostic performances of ct attenuation corrected and non-attenuation corrected spect myocardial perfusion scintigraphy in coronary artery disease.
Rev Esp Med Nucl Imagen Mol (Engl Ed)
December 2024
Selcuk University Medical Faculty, Department of Nuclear Medicine, Konya, Turkey.
Introduction And Objectives: Tissue attenuation reduces the specificity of the myocardial perfusion imaging single photon emission tomography (SPECT), which leads reduced diagnostic accuracy. The aim of this study is to compare performances of non-attenuation corrected (NAC), computed tomography based-attenuation corrected (AC) and prone images for qualitative and semi-quantitative analysis of myocardial perfusion SPECT in diagnosis of coronary artery disease (CAD).
Materials And Methods: Eightysix patients in whom NAC, AC and prone images were obtained with SPECT at Selcuk University Faculty of Medicine, and whose coronary angiography/CT coronary angiography was completed within 3 months, were retrospectively studied.
Working memory processes and the histamine-3 receptor in schizophrenia: a [C]MK-8278 PET-fMRI study.
Psychopharmacology (Berl)
December 2024
Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, Kings College London, De Crespigny Park, London, SE5 8AF, UK.
Rationale: Working memory impairment is a prominent feature of schizophrenia which predicts clinical and functional outcomes. Preclinical data suggest histamine-3 receptor (H3R) expression in cortical pyramidal neurons may have a role in working memory, and post-mortem data has found disruptions of H3R expression in schizophrenia.
Objectives: We examined the role of H3R in vivo to elucidate its role on working memory impairment in schizophrenia.
Health equity and distributive justice: views of high-level African policymakers.
BMC Med Ethics
December 2024
Takemi Program in International Health, Harvard T.H. Chan School of Public Health, Harvard University, 665 Huntington Avenue, Bldg. 1, Boston, MA, 02115-6021, USA.
Health equity matters, but there is no universally accepted definition of this or associated terms, such as inequities, inequalities, and disparities. Given the flexibility of these terms, investigating how policymakers understand them is important to observe priorities and perhaps course correct. Accordingly, this study analyzed the perceptions high-level policymakers within the WHO African Region.
View Article and Find Full Text PDFAssessing the comparative effects of interventions in COPD: a tutorial on network meta-analysis for clinicians.
Respir Res
December 2024
University of Exeter Medical School, College of Medicine and Health, University of Exeter, Exeter, UK.
To optimize patient outcomes, healthcare decisions should be based on the most up-to-date high-quality evidence. Randomized controlled trials (RCTs) are vital for demonstrating the efficacy of interventions; however, information on how an intervention compares to already available treatments and/or fits into treatment algorithms is sometimes limited. Although different therapeutic classes are available for the treatment of chronic obstructive pulmonary disease (COPD), assessing the relative efficacy of these treatments is challenging.
View Article and Find Full Text PDFFedPD: Defending federated prototype learning against backdoor attacks.
Neural Netw
December 2024
College of Mechanical and Information Engineering, Putian, 351100, China. Electronic address:
Federated Learning (FL) is an efficient, distributed machine learning paradigm that enables multiple clients to jointly train high-performance deep learning models while maintaining training data locally. However, due to its distributed computing nature, malicious clients can manipulate the prediction of the trained model through backdoor attacks. Existing defense methods require significant computational and communication overhead during the training or testing phases, limiting their practicality in resource-constrained scenarios and being unsuitable for the Non-IID data distribution typical in general FL scenarios.
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