Enal-azomethine ylides: application in the synthesis of functionalized pyrroles.

Rhodium-catalyzed [3 + 2] annulation of diazoenals and -alkyl imines resulted in -alkyl-pyrrole-3-carbaldehyde derivatives. The reaction involves thermal 6π-electrocyclization and aromatization of a new class of enal-azomethine ylides (EAYs). The EAYs derived from dihydroisoquinoline and 2-azirine gave fused-pyrrole and pyridine derivatives, respectively. The synthetic importance of pyrrole products has been demonstrated by one-step synthesis of the biologically relevant pyrrolo[3,2-]quinoline scaffold as well as pyrrolo[2,1-]isoquinoline which is a core structure of lamellarin alkaloids.