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Assessment of cognitive and psychiatric disturbances in people with post-COVID-19 condition: a cross-sectional observational study.
CNS Spectr
November 2024
Neuroscience Research Center, Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy.
Objective: Cognitive and psychiatric symptoms have been increasingly reported after severe acute respiratory syndrome coronavirus 2 infection, developing soon after infection and possibly persisting for several months. We aimed to study this syndrome and start implementing strategies for its assessment.
Methods: Consecutive patients, referred by the infectious disease specialist because of cognitive complaints after COVID-19, were neurologically evaluated.
Combination of rituximab and low-dose glucocorticoids for idiopathic refractory nephrotic syndrome with MCD/FSGS: a single-center prospective cohort study.
Ren Fail
December 2024
Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Background: The treatment of idiopathic refractory nephrotic syndrome (IRNS) remains a difficult problem in clinical practice. This study aims to determine the efficacy and safety of combining low-dose glucocorticoids with rituximab in IRNS treatment.
Methods: This prospective, single-center cohort study enrolled 60 patients who were diagnosed with refractory IRNS with minimal change disease (MCD) or focal segmental glomerulosclerosis (FSGS) and treated at First Affiliated Hospital of Sun Yat-sen University.
Predictive modeling of hepatitis B viral dynamics: a caputo derivative-based approach using artificial neural networks.
Sci Rep
September 2024
Department of Basic, Sciences College of science and theoretical studies, Saudi Electronic University, Riyadh, 11673, Saudi Arabia.
A fractional model for the kinetics of hepatitis B transmission was developed. The hepatitis B virus significantly affects the world's economic and health systems. Acute and chronic carrier phases play a crucial part in the spread of the HBV infection.
View Article and Find Full Text PDFEngineering the bacteriophage 80 alpha endolysin as a fast and ultrasensitive detection toolbox against Staphylococcus aureus.
Biosens Bioelectron
December 2024
School of Food and Biological Engineering, Chengdu University, Chengdu, 610106, China; School of Basic Medical Sciences, Chengdu University, Chengdu, 610106, China; Engineering Research Center of Sichuan-Xizang Traditional Medicinal Plant, Chengdu University, Chengdu, 610106, China. Electronic address:
The isolation and identification of pathogenic bacteria from a variety of samples are critical for controlling bacterial infection-related health problems. The conventional methods, such as plate counting and polymerase chain reaction-based approaches, tend to be time-consuming and reliant on specific instruments, severely limiting the effective identification of these pathogens. In this study, we employed the specificity of the cell wall-binding (CBD) domain of the Staphylococcus aureus bacteriophage 80 alpha (80α) endolysin towards the host bacteria for isolation.
View Article and Find Full Text PDFMixed-charge hyperbranched polymer nanoparticles with selective antibacterial action for fighting antimicrobial resistance.
Acta Biomater
November 2024
Key Laboratory of Macromolecular Synthesis and Functionalization (Ministry of Education), Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China; Center of Healthcare Materials, Shaoxing Institute, Zhejiang University, Shaoxing 312000, China. Electronic address:
The escalating menace of antimicrobial resistance (AMR) presents a profound global threat to life and assets. However, the incapacity of metal ions/reactive oxygen species (ROS) or the indiscriminate intrinsic interaction of cationic groups to distinguish between bacteria and mammalian cells undermines the essential selectivity required in these nanomaterials for an ideal antimicrobial agent. Hence, we devised and synthesized a range of biocompatible mixed-charge hyperbranched polymer nanoparticles (MCHPNs) incorporating cationic, anionic, and neutral alkyl groups to effectively combat multidrug-resistant bacteria and mitigate AMR.
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