AI Article Synopsis
- Alzheimer's disease (AD) research is gaining momentum due to the aging population, highlighting the need to understand its biological aspects.
- A new near-infrared (NIR) fluorescent probe (DCM-Cl-Acr) has been developed to selectively image cysteine (Cys), showing high sensitivity and low detection limits.
- The probe has been effectively used to visualize Cys levels in living cells and zebrafish, demonstrating significant accumulation in AD mouse models, suggesting a link between Cys concentration and Alzheimer's disease.
Article Abstract
Alzheimer's disease (AD) has gradually received enthusiastic attention with the aging process, and studying its biological relevance is expected. Excitingly, fluorescence probes were considered to be powerful tools for exploring biological correlations. Therefore, a highly selective near-infrared (NIR) fluorescent probe (DCM-Cl-Acr) for imaging cysteine (Cys) in AD was designed and synthesized. Through structural optimization, the probe exhibited high fluorescence quantum yield and low detection limit (20 nM) towards Cys. Meanwhile, based on the high selectivity and high sensitivity response exhibited by the probe to Cys, it was successfully applied to visualize endogenous and exogenous Cys in living cells and zebrafish, and showed good discrimination from homocysteine (Hcy) and glutathione (GSH). Further, the correlation between AD and Cys concentration was clarified by imaging studies in hippocampus tissue of AD mouse, and the abnormal accumulation of Cys in the hippocampus of AD brain was demonstrated.
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| http://dx.doi.org/10.1016/j.talanta.2024.126482 | DOI Listing |
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