AI Article Synopsis
- The study looked at mental and emotional symptoms in people with advanced breast cancer and how these symptoms related to individual traits and blood-test results.
- They studied 201 patients in western Pennsylvania and found three types of symptoms: mild, moderate, and severe mood-related symptoms.
- A specific gene change (TP53 deletion) linked to more severe symptoms was found, which could help doctors predict and better manage these symptoms in cancer patients.
Article Abstract
Objectives: To phenotype the psychoneurologic (PN) symptom cluster in individuals with metastatic breast cancer and associate those phenotypes with individual characteristics and cancer genomic variables from circulating tumor DNA.
Sample & Setting: This study included 201 individuals with metastatic breast cancer recruited in western Pennsylvania.
Methods & Variables: A descriptive, cross-sectional design was used. Symptom data were collected via the MD Anderson Symptom Inventory, and cancer genomic data were collected via ultra-low-pass whole-genome sequencing of circulating tumor DNA from participant blood.
Results: Three distinct PN symptom phenotypes were described in a population with metastatic breast cancer: mild symptoms, moderate symptoms, and severe mood-related symptoms. Breast cancer TP53 deletion was significantly associated with membership in a moderate to severe symptoms phenotype (p = 0.013).
Implications For Nursing: Specific cancer genomic changes associated with increased genomic instability may be predictive of PN symptoms. This finding may enable proactive treatment or reveal new therapeutic targets for symptom management.
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| http://dx.doi.org/10.1188/24.ONF.391-403 | DOI Listing |
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