Germline activating mutations in STAT3 cause a multi-systemic autoimmune and autoinflammatory condition. By studying a mouse model, Toth et al. (https://doi.org/10.1084/jem.20232091) propose a role for dysregulated IL-22 production by Th17 cells in causing some aspects of immune-mediated skin inflammation in human STAT3 GOF syndrome.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11215521PMC
http://dx.doi.org/10.1084/jem.20240849DOI Listing

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