FOXP3 hijacks DNA-binding proteins to regulate gene expression. In this issue of JEM, He et al. (https://doi.org/10.1084/jem.20232068) propose a dynamic model in which FOXP3 associates with DNA-binding proteins to regulate Treg cell function in response to environmental cues.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11215522PMC
http://dx.doi.org/10.1084/jem.20240940DOI Listing

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