By integrating health coaching into maritime medical clinics, we can provide tailored support to individuals at risk of developing diabetes and empower them to take control of their health.
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Consensus Recommendations for the Management of Neurosarcoidosis: A Delphi Survey of Experts Across the United States.
Neurol Clin Pract
April 2025
Department of Neurology, New York University Langone Health.
Background And Objectives: Neurosarcoidosis poses a diagnostic and management challenge due to its rarity, phenotypic variability, and lack of randomized controlled studies to guide treatment selection. Recommendations for management based on expert opinion are useful in clinical practice and provide a framework for designing prospective studies.
Methods: In this Delphi survey study, specialists with experience in managing patients with neurosarcoidosis were invited to anonymously complete 2 surveys about key elements of evaluation, diagnosis, treatment, monitoring, and long-term management of neurosarcoidosis.
Breakthrough Psoriasis in Patients Receiving Biologicals.
Psoriasis (Auckl)
January 2025
Department of Dermatology and Venerology, CHU of Sart Tilman, University of Liège B-4000, Liège, Belgium.
Background: Biological therapies, including TNF-alpha, IL12/23, IL17 and IL23 antagonists, adequately control a very high number of patients with moderate-to-severe psoriasis with an excellent long-term safety profile. However, on occasion, patients on biological therapy with stabilized disease or complete remission report episodes of sudden breakthrough psoriasis.
Aim: To study prospectively in a monocentric tertiary setting, the clinical characteristics of patients presenting a sudden breakthrough psoriasis although completely stabilized (PASI 90-100) under biological therapy.
Targeting interleukin-6 pathways in giant cell arteritis management: A narrative review of evidence.
Autoimmun Rev
January 2025
Department of Autoimmune Diseases, Institut D'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), University of Barcelona, Gran Via de les Corts Catalanes, 585, L'Eixample, 08007 Barcelona, Spain.
Giant cell arteritis (GCA) is a chronic inflammatory vasculitis with a significant impact on vascular and patient health. It may present with non-specific symptoms and can lead to severe complications if not managed effectively. This narrative review explores the treatment of GCA with interleukin-6 (IL-6) pathway inhibitors, focusing on key studies from selected databases published between 2018 and 2024.
View Article and Find Full Text PDFTracking the course of depressive and anxiety symptoms across adolescence (the CATS study): a population-based cohort study in Australia.
Lancet Psychiatry
January 2025
Murdoch Children's Research Institute, Melbourne, VIC, Australia; Centre for Adolescent Health, Royal Children's Hospital, Melbourne, VIC, Australia; Department of Paediatrics, The University of Melbourne, Melbourne, VIC, Australia; School of Psychology, Faculty of Health, Deakin University, Burwood, VIC, Australia.
Background: Adolescent mental health appears to be in crisis, yet few studies have comprehensively charted the course of common mental disorders (CMDs; depression and anxiety) across this key life stage. We aimed to describe the course of CMD symptoms in adolescence by summarising annual prevalence, cumulative incidence, and course for depression and anxiety, both separately and as comorbid CMDs, by sex assigned at birth in a contemporary Australian cohort.
Methods: The Child to Adult Transition Study (CATS) was established in 2012 to form a representative cohort of adolescents in Melbourne, VIC, Australia.
Infection-Associated Flares in Systemic Lupus Erythematosus.
Pathogens
October 2024
Unit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy.
Article Synopsis
- Systemic lupus erythematosus (SLE) leads to immune dysfunction and increased infection susceptibility, often resulting in infection-associated flares (IAFs) that can resolve alongside infections.
- In a study of 2,039 visits, researchers identified 134 flares (17% yearly deterioration of lupus low disease activity state [LLDAS]), with 38 classified as IAFs primarily linked to bacterial and herpesvirus infections.
- IAFs showed similar or greater severity in symptoms compared to other flares, with distinct characteristics such as lower anti-DNA antibody levels in viral IAFs, indicating the need for further research to explore these differences and improve treatment approaches.
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