One new canthinone glycoside (), together with six known compounds (-) including three lignans (-), two coumarins (- and one phenol ( was isolated from the root barks of . The structure of new compound was established by the interpretation of UV, IR, MS and NMR data, while its absolute configuration was determined by acid hydrolysis and GIAO NMR calculations with DP4+ probability analysis. The inhibitory effects of all compounds on Nitric oxide (NO) production were investigated in lipopolysaccharide (LPS)-induced RAW 264.7 cells. Results showed that compounds and displayed NO production inhibitory activity with IC values of 30.1 and 15.3 M, respectively.
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http://dx.doi.org/10.1080/10286020.2024.2360047 | DOI Listing |
J Asian Nat Prod Res
October 2024
College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China.
One new canthinone glycoside (), together with six known compounds (-) including three lignans (-), two coumarins (- and one phenol ( was isolated from the root barks of . The structure of new compound was established by the interpretation of UV, IR, MS and NMR data, while its absolute configuration was determined by acid hydrolysis and GIAO NMR calculations with DP4+ probability analysis. The inhibitory effects of all compounds on Nitric oxide (NO) production were investigated in lipopolysaccharide (LPS)-induced RAW 264.
View Article and Find Full Text PDFMolecules
December 2019
Centre for Natural Products Discovery (CNPD), School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, James Parsons Building, Byrom Street, Liverpool L3 3AF, UK.
A phytochemical study of the root and bark of J. F. Mill.
View Article and Find Full Text PDFBioorg Med Chem Lett
March 2015
College of Pharmacy, Kyung Hee University, Seoul 130-701, Republic of Korea; Department of Life & Nanopharmaceutical Science, Kyung Hee University, Seoul 130-701, Republic of Korea. Electronic address:
Three new canthinone type alkaloids, canthin-6-one-1-O-β-D-apiofuranosyl-(1→2)-β-D-glucopyranoside (1), canthin-6-one-1-O-[6-O-(3-hydroxy-3-methylglutaryl)]-β-D-glucopyranoside (2) and canthin-6-one-1-O-[2-β-D-apiofuranosyl-6-O-(3-hydroxy-3-methylglutaryl)]-β-D-glucopyranoside (3) were isolated from the stem barks of Ailanthus altissima together with four quassinoids (4-7), seven phenylpropanoids (8-14) and a lignan of previously known structure (15). The inflammatory activities of the 15 isolates were screened on LPS-induced nitric oxide (NO), a proinflammatory mediator, in RAW 264.7 cells.
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