The editorial introduces the Special Section on Molecular Neurophotonics.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11213545 | PMC |
| http://dx.doi.org/10.1117/1.NPh.11.2.024200 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Transcriptional determinants of goal-directed learning and representational drift in the parahippocampal cortex.
Cell Rep
January 2025
Department of Biology, Boston University, Boston, MA 02215, USA; Center for Neurophotonics, Boston University, Boston, MA 02215, USA; Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA; Center for Systems Neuroscience, Boston University, Boston MA 02215, USA. Electronic address:
Article Synopsis
- Task learning involves forming and storing associations between stimuli and outcomes in memory, but individual neuron representations can change over time.
- Researchers used two-photon calcium imaging and spatial transcriptomics to study neuron activity and gene expression in the perirhinal cortex during task training.
- Deleting brain-derived neurotrophic factor disrupted gene expression and task learning, while prolonged training reduced representational drift and strengthened existing memory representations, highlighting key cellular mechanisms in memory stability.
Distribution of spine classes shows intra-neuronal dendritic heterogeneity in mouse cortex.
Neurophotonics
January 2025
Saarland University, Molecular Imaging, Center for Integrative Physiology and Molecular Medicine, Homburg, Germany.
Significance: Neuronal dendritic spines are central elements for memory and learning. Their morphology correlates with synaptic strength and is a proxy for function. Classic light microscopy cannot resolve spine morphology well, and techniques with higher resolution (electron microscopy and super-resolution light microscopy) typically do not provide spine data in large fields of view, e.
View Article and Find Full Text PDFExpansion microscopy reveals neural circuit organization in genetic animal models.
Neurophotonics
January 2025
New Jersey Institute of Technology, Federated Department of Biological Sciences, Newark, New Jersey, United States.
Expansion microscopy is a super-resolution technique in which physically enlarging the samples in an isotropic manner increases inter-molecular distances such that nano-scale structures can be resolved using light microscopy. This is particularly useful in neuroscience as many important structures are smaller than the diffraction limit. Since its invention in 2015, a variety of expansion microscopy protocols have been generated and applied to advance knowledge in many prominent organisms in neuroscience, including zebrafish, mice, , and .
View Article and Find Full Text PDFGSK3β phosphorylation catalyzes the aggregation of tau into Alzheimer's disease-like filaments.
Proc Natl Acad Sci U S A
December 2024
Department for NMR-based Structural Biology, Max Planck Institute for Multidisciplinary Sciences, Göttingen 37077, Germany.
The pathological deposition of proteins is a hallmark of several devastating neurodegenerative diseases. These pathological deposits comprise aggregates of proteins that adopt distinct structures named strains. However, the molecular factors responsible for the formation of distinct aggregate strains are unknown.
View Article and Find Full Text PDFImplementation and validation of single-cell genomics experiments in neuroscience.
Nat Neurosci
December 2024
Edmond & Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel.
Single-cell or single-nucleus transcriptomics is a powerful tool for identifying cell types and cell states. However, hypotheses derived from these assays, including gene expression information, require validation, and their functional relevance needs to be established. The choice of validation depends on numerous factors.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!