AI Article Synopsis
- Anastomotic leaks are serious complications in gastrointestinal surgeries that significantly affect patients' recovery and quality of life, necessitating more research into effective healing methods.
- The aim of this study was to review experimental protocols used in high-risk anastomosis in rats, following established systematic review guidelines for credibility.
- Although 102 relevant studies were identified and analyzed for methods of creating and assessing high-risk anastomosis, there is still a lack of translation of findings to human applications, highlighting the need for more rigorous research in this area.
Article Abstract
Background: Anastomotic leaks remain one of the most dreaded complications in gastrointestinal surgery causing significant morbidity, that negatively affect the patients' quality of life. Experimental studies play an important role in understanding the pathophysiological background of anastomotic healing and there are still many fields that require further investigation. Knowledge drawn from these studies can lead to interventions or techniques that can reduce the risk of anastomotic leak in patients with high-risk features. Despite the advances in experimental protocols and techniques, designing a high-quality study is still challenging for the investigators as there is a plethora of different models used.
Aim: To review current state of the art for experimental protocols in high-risk anastomosis in rats.
Methods: This systematic review was performed according to The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. To identify eligible studies, a comprehensive literature search was performed in the electronic databases PubMed (MEDLINE) and Scopus, covering the period from conception until 18 October 2023.
Results: From our search strategy 102 studies were included and were categorized based on the mechanism used to create a high-risk anastomosis. Methods of assessing anastomotic healing were extracted and were individually appraised.
Conclusion: Anastomotic healing studies have evolved over the last decades, but the findings are yet to be translated into human studies. There is a need for high-quality, well-designed studies that will help to the better understanding of the pathophysiology of anastomotic healing and the effects of various interventions.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11212746 | PMC |
| http://dx.doi.org/10.5493/wjem.v14.i2.94135 | DOI Listing |
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