AI Article Synopsis
- Disulfide compounds play a crucial role in cell function, and their abnormal buildup can cause a new type of cell death called disulfidptosis, which is distinct from other forms of cell death.
- A study analyzed data from The Cancer Genome Atlas to identify differentially expressed genes and created a prognostic model using 11 key genes to assess risk levels in endometrial carcinoma patients.
- The model successfully categorized patients into high-risk and low-risk groups based on survival, tumor characteristics, and treatment response, suggesting it could aid in personalized treatment approaches for endometrial cancer.
Article Abstract
Background: Disulfide, an essential compounds family, has diverse biological activity and can affect the dynamic balance between physiological and pathological states. A recently published study found that aberrant accumulation of disulfide had a lethal effect on cells. This mechanism of cell death, named disulfidptosis, differs from other known cell death mechanisms, including cuproptosis, apoptosis, necroptosis, and pyroptosis. The relationship between disulfidptosis and development of cancer, in particular endometrial carcinoma, remains unclear.
Methods: To address this knowledge gap, we performed a preliminary analysis of samples from The Cancer Genome Atlas database. The samples were divided equally into a training group and a test group. A total of 2308 differentially expressed genes were extracted, and 11 were used to construct a prognostic model.
Results: Based on the risk score calculated using the prognostic model, the samples were divided into a high-risk group and a low-risk group. Survival time, tumor mutation burden, and microsatellite instability scores differed significantly between the two groups. Furthermore, a between-group difference in treatment effect was predicted. Comparison with other models in the literature indicated that this prognostic model had better predictive anility.
Conclusion: The results of this study provide a general framework for understanding the relationship between disulfidptosis and endometrial cancer that could be used for clinical evaluation and selection of appropriate personalized treatment strategies.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11212335 | PMC |
| http://dx.doi.org/10.1002/cai2.120 | DOI Listing |
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