AI Article Synopsis
- This study examined how calorie restriction (CR) affects the elemental content and stable isotope ratios in bone collagen and hair keratin in adult mice over a period of 84 days.
- Mice on higher CR (10-40%) showed decreased nitrogen, carbon, and sulfur levels in their hair, while bone collagen nitrogen levels increased and carbon levels decreased.
- The findings suggest that changes in the structure of bone collagen and the mobilization of proteins during CR complicate the use of elemental measurements for assessing collagen quality in archaeological contexts, especially where nutrition might be a concern.
Article Abstract
This study characterized the effect of calorie restriction (CR) on elemental content and stable isotope ratio measurements of bone "collagen" and hair keratin. Adult mice on graded CR (10-40%; 84 days) showed decreased hair N, C, and S values (significantly for N) with increasing CR, alongside a significant increase in bone "collagen" N values and a decrease in "collagen" C values. We propose this was likely due to the intensified mobilization of endogenous proteins, as well as lipids in newly synthesized "collagen". Elemental analysis of bone "collagen" revealed decreased carbon, nitrogen, and sulfur % content with increasing CR which is attributed to a change in the bone "collagen" structure with extent of CR. This complexity challenges the use of elemental indicators in the assessment of collagen quality in archaeological studies where nutritional stress may be a factor.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11214416 | PMC |
| http://dx.doi.org/10.1016/j.isci.2024.110059 | DOI Listing |
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