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Setting a research agenda for examining early risk for elevated cognitive disengagement syndrome symptoms using data from the ABCD cohort. | LitMetric

AI Article Synopsis

  • The study examines how early life risk factors affect symptoms of cognitive disengagement syndrome (CDS) in children aged 9-10, particularly in a large sample from the Adolescent Brain Cognitive Development (ABCD) study.
  • Significant associations were found between elevated CDS symptoms and various risk factors including parental circumstances, pregnancy complications, and delays in developmental milestones.
  • The research highlights the need for further investigation into these early-life factors, emphasizing their potential common origins and impacts on children's cognitive development, while noting that causal relationships cannot be determined from this design.

Article Abstract

Background: Little research has examined early life risk for symptoms of cognitive disengagement syndrome (CDS) despite a well-established literature regarding co-occurring outcomes (e.g., attention-deficit/hyperactivity disorder). The current study estimated bivariate associations between early life risk factors and CDS in a large and representative sample of U.S. children.

Methods: We conducted secondary analyses of baseline data from the Adolescent Brain Cognitive Development (ABCD) study (N = 8,096 children, 9-10 years old). Birthing parents reported early life risk factors on a developmental history questionnaire, including parental, prenatal, delivery and birth, and developmental milestone information. They also completed the Child Behavior Checklist, which includes a CDS subscale that was dichotomized to estimate the odds of elevated CDS symptoms (i.e., -score > 70) in children related to risk indices.

Results: We observed significantly elevated odds of CDS related to parental risk factors (i.e., unplanned pregnancy, pregnancy awareness after 6 weeks, teenage parenthood), birthing parent illnesses in pregnancy (i.e., severe nausea, proteinuria, pre-eclampsia/toxemia, severe anemia, urinary tract infection), pregnancy complications (i.e., bleeding), prenatal substance exposures (i.e., prescription medication, tobacco, illicit drugs), delivery and birth risk factors (i.e., child blue at delivery, child not breathing, jaundice, incubation after delivery), and late motor and speech milestones in children.

Conclusions: Several early-life risk factors were associated with elevated odds of CDS at ages 9-10 years; study design prevents the determination of causality. Further investigation is warranted regarding early life origins of CDS with priority given to risk indices that have upstream commonalities (i.e., that restrict fetal growth, nutrients, and oxygen).

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11213211PMC
http://dx.doi.org/10.21203/rs.3.rs-4468007/v1DOI Listing

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