The chemical investigation of the methanol trunk bark extract of led to the isolation of a new flavanone, 5,7,4'-trihydroxy-3',5'-bis(3-methylbutadienyl)flavanone (trivially named senegalensisnone) (), together with seven known compounds, abyssinone-V-4'--methyl ether (), abyssinone V (), Calopocarpin (), genistein ) mixture of stigmasterol () and -sitosterol () and -sitosterol-3---D-glucopyranoside (). The structures of the isolates were elucidated by extensive spectroscopic and spectrometric analyses (1D and 2D NMR, ESI-MS) and by comparison with previously reported data. The absolute configuration of was deduced based on comparison of its experimental CD with that of similar compound. All the compounds were tested for their antibacterial, antifungal and antioxidant activities. Compound displayed weak antibacterial activity against with MIC value of 62.5 g/mL. All the isolates were found to be inactive as antioxidant agents in the DPPH, ABTS and FRAP assays.
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http://dx.doi.org/10.1080/14786419.2024.2364258 | DOI Listing |
Int J Mol Sci
January 2025
Key Laboratory of Xinjiang Phytomedicine Resource and Uilization, Ministry of Education, Shihezi 832002, China.
belongs to the family Euphorbiaceae and is widely distributed in northern Xinjiang, making it a characteristic plant of the region in Xinjiang, China. The chemical composition and biological activity of have not yet been reported, although certain compounds isolated from plants in Xinjiang, China, have demonstrated exceptional multidrug resistance (MDR) reversal. This study aims to investigate the chemical components present in with the potential to reverse MDR.
View Article and Find Full Text PDFPlants (Basel)
December 2024
N.I. Vavilov All-Russian Institute of Plant Genetic Resources, B. Morskaya 42-44, 190000 Saint-Petersburg, Russia.
A comparative metabolomic study of three varieties of wild Rosa (, , and ) from a Kamchatka expedition (2024) was conducted via extraction with supercritical carbon dioxide modified with ethanol (EtOH), and detection of bioactive compounds was realized via tandem mass spectrometry. Several experimental conditions were investigated in the pressure range 50-350 bar, with the used volume of co-solvent ethanol in the amount of 2% in the liquid phase at a temperature in the range of 31-70 °C. The most effective extraction conditions are the following: pressure 200 Bar and temperature 55 °C for ; pressure 250 Bar and temperature 60 °C for ; pressure 200 Bar and temperature 60 °C for .
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December 2024
Chengdu Normal University, Sichuan Provincial Key Laboratory for Development and Utilization of Characteristic Horticulural Biological Resources, Chengdu Normal University, Chengdu, Sichuan, China.
Background: , a perennial herbaceous medicinal plant, is extensively utilized in the pharmaceutical industry. The growth of is frequently constrained by soil phosphorus availability, as a significant portion of arable land in China suffers from phosphorus deficiency.
Method: This study utilized Ural Fisch as the subject and examined the application of GR24, a synthetic strigolactone, under three phosphorus conditions: none (P1), low (P2), and high (P3).
J Ethnopharmacol
February 2025
Institute of Pathology, University Hospital Schleswig-Holstein, 23538, Luebeck, Germany.
Ethnopharmacological Relevance: Commiphora kerstingii Engl is a tree which is 20-30 m in height and commonly called "ararrabi" in Hausa. It is found in the Sahelian region (Cameroon, Chad, and Nigeria) where it is utilized for the treatment of several ailments including cancer.
Aim Of The Study: This study was aimed at investigating the chemical constituents and cytotoxic effect of extracts and isolates from the stem barks and leaves of C.
Chin J Nat Med
November 2024
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China. Electronic address:
Six novel compounds, comprising three quinolones (1a, 1b, and 2) and three flavanones (3-5), along with seven known analogs (6-13), were isolated from the 95% EtOH extract of the stems and leaves of Glycosmis craibii var. glabra. The structures of the new compounds were elucidated using HR-ESI-MS, UV, and 1D and 2D nuclear magnetic resonance (NMR) data analysis.
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