Pan-RAF:MEK Molecular Glues Take Center Stage.

Cancer Discov

UCSD Moores Cancer Center, University of California San Diego, La Jolla, California.

Published: July 2024

In this issue, Ryan and colleagues describe the preclinical development of a pan-RAF:MEK molecular glue with superior efficacy, brain penetrance, and tolerability in xenograft models of Ras/Raf/MAPK pathway-driven tumors. See related article by Ryan et al., p. 1190 (1).

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Source
http://dx.doi.org/10.1158/2159-8290.CD-24-0539DOI Listing

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