Mitochondrial regulation of erythropoiesis in homeostasis and disease.

Br J Haematol

Department of Cell, Developmental & Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Published: August 2024

AI Article Synopsis

  • Erythroid cells mature into red blood cells (RBCs) through a complex process involving chromatin condensation, nuclear polarization, and enucleation, resulting in mature RBCs rich in hemoglobin.
  • Recent research indicates that mitochondria play an active role in erythroid maturation and RBC production, despite healthy RBCs lacking these organelles.
  • Understanding mitochondrial involvement is crucial, as abnormal retention of mitochondria in RBCs can lead to diseases like sickle cell anemia.

Article Abstract

Erythroid cells undergo a highly complex maturation process, resulting in dynamic changes that generate red blood cells (RBCs) highly rich in haemoglobin. The end stages of the erythroid cell maturation process primarily include chromatin condensation and nuclear polarization, followed by nuclear expulsion called enucleation and clearance of mitochondria and other organelles to finally generate mature RBCs. While healthy RBCs are devoid of mitochondria, recent evidence suggests that mitochondria are actively implicated in the processes of erythroid cell maturation, erythroblast enucleation and RBC production. However, the extent of mitochondrial participation that occurs during these ultimate steps is not completely understood. This is specifically important since abnormal RBC retention of mitochondria or mitochondrial DNA contributes to the pathophysiology of sickle cell and other disorders. Here we review some of the key findings so far that elucidate the importance of this process in various aspects of erythroid maturation and RBC production under homeostasis and disease conditions.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11619715PMC
http://dx.doi.org/10.1111/bjh.19600DOI Listing

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