AI Article Synopsis
- * The method uses a specific column setup and conditions, including a mobile phase of 50% phosphate buffer and 50% acetonitrile, with a total run time of 20 minutes.
- * Results show that the method is valid and effective in detecting stability under various stress conditions, making it suitable for routine quality control in the pharmaceutical industry.
Article Abstract
Objective: The present work represents a reverse-phase high-performance liquid chromatography method in addition to stability studies for sequential estimation of remogliflozin etabonate, vildagliptin, and metformin HCl in tablet formulation.
Method: The mentioned method utilizes a Phenomenex Luna C18 column (250×4.6mm, 5μm). It consists of a column oven's temperature of 35°C. Mobile phase includes a mixture of 50% phosphate buffer (pH - 6.8) and 50% acetonitrile along with a flow rate of 0.8mL/min and 20minutes of run time. The injection volume was 20μL; 217nm is a detection wavelength, and a PDA detector is used for detection.
Results: The suggested technique was proven and validated per the ICH Q2 (R1) guideline. The combination was put under stress conditions that included acid, base, thermal, photolytic, and oxidative degradation. The combination was considerably degraded under oxidative, acidic, and basic circumstances for deterioration, and the degradation results were accurately identified from the observed peaks, demonstrating the method's effectiveness in detecting stability.
Conclusion: The technique was quick, precise, sensitive, and accurate; as a result, it may be used in quality control laboratories and the pharmaceutical industry for routine quality monitoring of tablets containing all three medications.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.pharma.2024.06.006 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Association of statins, gliptins, and antipsychotics with bullous pemphigoid: A case-control study in the Cretan population.
J Dermatol
January 2025
School of Medicine, University of Crete, Heraklion, Greece.
Bullous pemphigoid (BP) is an autoimmune blistering disorder predominantly affecting the elderly. Recently, many studies have shed light on the effect of specific drug intake and comorbidities on the development of BP. The purpose of this study was to investigate the association of specific drug class intake and comorbidities with the development of BP in the Cretan population.
View Article and Find Full Text PDFA prospective, multicentre study evaluating safety and efficacy of a fixed dose combination of Remogliflozin etabonate, Vildagliptin, and Metformin in Indian patients with type 2 diabetes mellitus (Triad-RMV).
Clin Diabetes Endocrinol
December 2024
Glenmark Pharmaceuticals, Mumbai, India.
Aims: The ICMR INDIAB-17 study revealed a diabetes prevalence of 11.4% in India, emphasizing the need for effective treatment for glycemic control. A Phase IV study was conducted to evaluate the safety and efficacy of a Fixed Dose Combination (FDC) of Remogliflozin, Metformin and Vildagliptin (RMV) in Type 2 Diabetes Mellitus (T2DM) patients uncontrolled on Metformin plus SGLT2 inhibitor or Metformin plus DPP4 inhibitor dual therapy.
View Article and Find Full Text PDFThe effect of vildagliptin versus metformin on hepatic steatosis in type 2 diabetic patients: a randomized controlled trial.
BMC Pharmacol Toxicol
December 2024
Internal Medicine Department, Faculty of Medicine, Minia University, Minia, Egypt.
Background: The risk of hepatic steatosis (HS) is elevated in patients with type 2 diabetes mellitus (T2D). Antidiabetic medications may contribute to the prevention or treatment of HS. This study aimed to compare the effects of vildagliptin and metformin on hepatic steatosis in newly diagnosed T2D patients, using the Hepatic Steatosis Index (HSI) and ultrasound grading.
View Article and Find Full Text PDFDrug-induced hearing disorders: a disproportionality analysis of the FAERS database.
Front Pharmacol
November 2024
Department of Pharmacy, Heping Hospital Affiliated to Changzhi Medical College, Changzhi, China.
Article Synopsis
- The study aimed to identify and evaluate reports of hearing impairment related to drugs approved in the last 20 years to enhance treatment safety.
- It analyzed adverse event data from the FAERS database and focused on "hearing disorders" to find potential new adverse reactions linked to specific medications.
- The findings highlighted the top five drugs most associated with hearing impairment incidents and identified new signals for drugs not previously linked to this side effect, indicating a need for caution with commonly prescribed medications.
Application of Fabric Phase Sorptive Extraction as a Green Method for the Analysis of 10 Anti-Diabetic Drugs in Environmental Water Samples.
Molecules
October 2024
Department of Chemistry, School of Science, University of Ioannina, 451110 Ioannina, Greece.
Due to the increased prevalence of diabetes, the consumption of anti-diabetic drugs for its treatment has likewise increased. Metformin is an anti-diabetic drug that is commonly prescribed for patients with type 2 diabetes and has been frequently detected in surface water and wastewaters, thus representing an emerging contaminant. Metformin can be prescribed in combination with other classes of anti-diabetic drugs; however, these drugs are not sufficiently investigated in environmental samples.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!