AI Article Synopsis
- The article reviews urethral reconstruction, discussing the types of grafts currently available, including natural, synthetic, and decellularized options.
- It highlights ongoing clinical trials and preclinical studies aimed at improving patient outcomes with these grafts, sometimes using cells or growth factors.
- The article also addresses commercialization challenges in urethral product development and identifies future obstacles and potential solutions in urethra engineering.
Article Abstract
Impact Statement The current article examines urethral reconstruction on three fronts: presently available grafts, clinical trials, and preclinical studies. In this context, studies have focused on various types of biomaterial grafts, including natural, synthetic, and decellularized, combined with or without cells or growth factors, aiming to improve outcomes at both clinical and pre-clinical stages. Subsequently, four stages in the commercialization regulatory pathway in urethra engineering were examined, focusing on the commercialization challenges, particularly those associated with urethral products. Finally, the forthcoming challenges in urethra engineering and potential solutions for its enhancement have been explored. [Figure: see text].
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| http://dx.doi.org/10.1089/ten.TEB.2024.0124 | DOI Listing |
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