AI Article Synopsis
- The study analyzed whole genome sequencing data from 1,751 individuals in the UK and 2,587 subjects from Qatar.
- Researchers found an association between rare variants in the sour taste gene KCNJ2 and lower levels of low-density lipoprotein cholesterol (LDL-C) and a 22% reduction in dietary trans-fat intake.
- This discovery highlights a potential new genetic factor that could influence LDL-C levels, which is important for understanding cardiovascular disease risks.
Article Abstract
Leveraging whole genome sequencing data of 1751 individuals from the UK and 2587 Qatari subjects, we suggest here an association of rare variants mapping to the sour taste-associated gene KCNJ2 with reduced low-density lipoprotein cholesterol (LDL-C, P = 2.10 × 10) and with a 22% decreased dietary trans-fat intake. This study identifies a novel candidate rare locus for LDL-C, adding insights into the genetic architecture of a complex trait implicated in cardiovascular disease.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11213907 | PMC |
| http://dx.doi.org/10.1038/s41525-024-00417-9 | DOI Listing |
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