AI Article Synopsis
- - High altitude pulmonary edema (HAPE) is a serious condition that can occur without heart involvement, and recent studies focus on identifying genetic factors linked to HAPE risk.
- - A genome-wide association study (GWAS) was conducted on 164 HAPE patients and 189 healthy controls from the Chinese Han population, using a large dataset of over 2.7 million genetic loci.
- - The research identified eight key genetic regions associated with HAPE and included analyses showing their roles in protein interactions, functional enrichment, and signaling pathways, enhancing our understanding of HAPE susceptibility.
Article Abstract
High altitude pulmonary edema (HAPE) is a life-threatening form of non-cardiogenic pulmonary edema. In recent years, association studies have become the main method for identifying HAPE genetic loci. A genome-wide association study (GWAS) of HAPE risk-associated loci was performed in Chinese male Han individuals (164 HAPE cases and 189 healthy controls) by the Precision Medicine Diversity Array Chip with 2,771,835 loci (Applied Biosystems Axiom™). Eight overlapping candidate loci in , , and were finally selected. functional analyses displayed the PPI network, functional enrichment and signal pathways related to , , and . This study provides data supplements for HAPE susceptibility gene loci and new insights into HAPE susceptibility.
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| http://dx.doi.org/10.1080/17410541.2024.2365617 | DOI Listing |
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