AI Article Synopsis
- - Eosinophilic esophagitis (EoE) is a chronic inflammatory disorder of the esophagus that causes symptoms like difficulty swallowing and food getting stuck, and it could lead to more serious complications like strictures.
- - The review discusses EoE's symptoms, progression, and current treatment strategies, with a focus on trials for biologic therapies aimed at managing inflammation.
- - Dupilumab is the first biologic approved for EoE, and while it shows promise, ongoing studies are needed to understand its long-term effects, with other new drugs also being tested that may change treatment approaches.
Article Abstract
Introduction: Eosinophilic esophagitis (EoE) is a chronic inflammatory, disabling disorder characterized by prominent eosinophilic inflammation of the esophagus, leading to troublesome symptoms including dysphagia and food impaction. The natural history of EoE is poorly known, but it may lead to esophageal strictures. The therapeutic armamentarium is expected to grow in the near future, especially due to the availability of novel biological therapies targeting crucial inflammatory pathways of EoE.
Areas Covered: In this review, we discuss the main clinical features and natural history of EoE, focusing on the current therapeutic strategies, as well as past and current trials investigating biologics for its treatment.
Expert Opinion: Dupilumab has been the first approved biologic drug for the treatment of EoE; long-term studies assessing how it could change the natural history of EoE are awaited. Novel biological drugs or other molecules are currently under study and could change the current treatment algorithms in the near future. Proper drug positioning and long term 'exit strategies' are yet to be defined.
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| http://dx.doi.org/10.1080/17474124.2024.2374471 | DOI Listing |
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